Literature DB >> 29081832

Using Principles of Behavioral Epigenetics to Advance Research on Early-Life Stress.

Elisabeth Conradt1.   

Abstract

While the negative effects of early-life stress on children's developmental outcomes are well documented, we know little about how these processes unfold and which children are more susceptible to these exposures. In this article, I outline how studying the effects of early-life stress on children's development can be advanced by considering how epigenetic processes may contribute to the emergence of children's behavior. The study of epigenetics can help pinpoint the mechanisms by which early-life stress may affect developmental outcomes and identify which children may be most sensitive to the effects of these exposures. I conclude by highlighting the challenges inherent in studying epigenetics in children and offer possible solutions.

Entities:  

Keywords:  DNA methylation; behavioral epigenetics; early-life stress

Year:  2017        PMID: 29081832      PMCID: PMC5658048          DOI: 10.1111/cdep.12219

Source DB:  PubMed          Journal:  Child Dev Perspect        ISSN: 1750-8592


  30 in total

Review 1.  Fetal programming by maternal stress: Insights from a conflict perspective.

Authors:  Marco Del Giudice
Journal:  Psychoneuroendocrinology       Date:  2012-06-12       Impact factor: 4.905

Review 2.  Epigenetics and the biological definition of gene x environment interactions.

Authors:  Michael J Meaney
Journal:  Child Dev       Date:  2010 Jan-Feb

3.  Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence.

Authors:  Marilyn J Essex; W Thomas Boyce; Clyde Hertzman; Lucia L Lam; Jeffrey M Armstrong; Sarah M A Neumann; Michael S Kobor
Journal:  Child Dev       Date:  2011-09-02

Review 4.  Development and the epigenome: the 'synapse' of gene-environment interplay.

Authors:  W Thomas Boyce; Michael S Kobor
Journal:  Dev Sci       Date:  2015-01

5.  Epigenetics: core misconcept.

Authors:  Mark Ptashne
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-12       Impact factor: 11.205

6.  Differential susceptibility to the environment: an evolutionary--neurodevelopmental theory.

Authors:  Bruce J Ellis; W Thomas Boyce; Jay Belsky; Marian J Bakermans-Kranenburg; Marinus H van Ijzendoorn
Journal:  Dev Psychopathol       Date:  2011-02

7.  Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses.

Authors:  Tim F Oberlander; Joanne Weinberg; Michael Papsdorf; Ruth Grunau; Shaila Misri; Angela M Devlin
Journal:  Epigenetics       Date:  2008 Mar-Apr       Impact factor: 4.528

Review 8.  Early experience and the development of stress reactivity and regulation in children.

Authors:  Michelle M Loman; Megan R Gunnar
Journal:  Neurosci Biobehav Rev       Date:  2009-05-27       Impact factor: 8.989

9.  Associations between early life stress and gene methylation in children.

Authors:  Sarah E Romens; Jennifer McDonald; John Svaren; Seth D Pollak
Journal:  Child Dev       Date:  2014-07-24

10.  An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication.

Authors:  Jolien Rijlaarsdam; Irene Pappa; Esther Walton; Marian J Bakermans-Kranenburg; Viara R Mileva-Seitz; Ralph C A Rippe; Sabine J Roza; Vincent W V Jaddoe; Frank C Verhulst; Janine F Felix; Charlotte A M Cecil; Caroline L Relton; Tom R Gaunt; Wendy McArdle; Jonathan Mill; Edward D Barker; Henning Tiemeier; Marinus H van IJzendoorn
Journal:  Epigenetics       Date:  2016-02-18       Impact factor: 4.528

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  6 in total

Review 1.  Early Caregiver-Child Interaction and Children's Development: Lessons from the St. Petersburg-USA Orphanage Intervention Research Project.

Authors:  Robert B McCall; Christina J Groark; Brandi N Hawk; Megan M Julian; Emily C Merz; Johana M Rosas; Rifkat J Muhamedrahimov; Oleg I Palmov; Natasha V Nikiforova
Journal:  Clin Child Fam Psychol Rev       Date:  2019-06

Review 2.  An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior.

Authors:  Elisabeth Conradt; Daniel E Adkins; Sheila E Crowell; Catherine Monk; Michael S Kobor
Journal:  Dev Psychopathol       Date:  2018-08

3.  Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers.

Authors:  Stephanie H Parade; Andrew M Novick; Justin Parent; Ronald Seifer; Samantha J Klaver; Carmen J Marsit; Asi Polly Gobin; Bao-Zhu Yang; Audrey R Tyrka
Journal:  Dev Psychopathol       Date:  2017-12

4.  DNA methylation of NR3c1 in infancy: Associations between maternal caregiving and infant sex.

Authors:  Elisabeth Conradt; Brendan Ostlund; Dylan Guerin; David A Armstrong; Carmen J Marsit; Edward Tronick; Lyn LaGasse; Barry M Lester
Journal:  Infant Ment Health J       Date:  2019-05-08

5.  Maternal Sensitivity Buffers the Association between SLC6A4 Methylation and Socio-Emotional Stress Response in 3-Month-Old Full Term, but not very Preterm Infants.

Authors:  Livio Provenzi; Monica Fumagalli; Roberto Giorda; Francesco Morandi; Ida Sirgiovanni; Uberto Pozzoli; Fabio Mosca; Renato Borgatti; Rosario Montirosso
Journal:  Front Psychiatry       Date:  2017-09-13       Impact factor: 4.157

6.  Methodological Challenges in Developmental Human Behavioral Epigenetics: Insights Into Study Design.

Authors:  Livio Provenzi; Maddalena Brambilla; Renato Borgatti; Rosario Montirosso
Journal:  Front Behav Neurosci       Date:  2018-11-23       Impact factor: 3.558

  6 in total

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