Literature DB >> 29080803

Dysregulation of methionine metabolism in multiple sclerosis.

N K Singhal1, E Freeman2, E Arning3, B Wasek3, R Clements2, C Sheppard4, P Blake4, T Bottiglieri3, J McDonough2.   

Abstract

We report a significant reduction in plasma methionine concentrations in relapse remitting multiple sclerosis (MS) patients compared to controls. In vivo studies demonstrate that changes in peripheral methionine levels in mice can regulate histone H3 methylation and expression of DNA methyltransferase 3A (DNMT3A) centrally, in the cerebral cortex. Therefore, we propose that decreases in circulating methionine represent one of the earliest manifestations of dysregulated methionine metabolism in MS with potential impacts on both histone H3 and DNA methylation in the central nervous system.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  DNA methyltransferases; Histone methylation; Methionine metabolism; Multiple sclerosis

Mesh：

Substances：

Year:  2017        PMID： 29080803     DOI： 10.1016/j.neuint.2017.10.011

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  12 in total

1.  Association of Methionine to Homocysteine Status With Brain Magnetic Resonance Imaging Measures and Risk of Dementia.

Authors:  Babak Hooshmand; Helga Refsum; A David Smith; Grégoria Kalpouzos; Francesca Mangialasche; Christine A F von Arnim; Ingemar Kåreholt; Miia Kivipelto; Laura Fratiglioni
Journal:  JAMA Psychiatry       Date:  2019-11-01       Impact factor: 21.596

Review 2.  The potential roles of amino acids and their major derivatives in the management of multiple sclerosis.

Authors:  Somayeh Pashaei; Reza Yarani; Pantea Mohammadi; Mohammad Sajad Emami Aleagha
Journal:  Amino Acids       Date:  2022-04-26       Impact factor: 3.520

3.  Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis.

Authors:  Naveen K Singhal; Sarah Sternbach; Sheila Fleming; Kholoud Alkhayer; John Shelestak; Daniela Popescu; Alyx Weaver; Robert Clements; Brandi Wasek; Teodoro Bottiglieri; Ernest J Freeman; Jennifer McDonough
Journal:  Epigenetics       Date:  2020-03-09       Impact factor: 4.528

4.  Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.

Authors:  James McKenna; David Kapfhamer; Jason M Kinchen; Brandi Wasek; Matthew Dunworth; Tracy Murray-Stewart; Teodoro Bottiglieri; Robert A Casero; Michael J Gambello
Journal:  Hum Mol Genet       Date:  2018-06-15       Impact factor: 6.150

5.  The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation.

Authors:  Sarah Sternbach; Nicole West; Naveen K Singhal; Robert Clements; Soumitra Basu; Ajai Tripathi; Ranjan Dutta; Ernest J Freeman; Jennifer McDonough
Journal:  PLoS One       Date:  2021-05-11       Impact factor: 3.240

6.  Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis.

Authors:  Stephanie Herman; Payam Emami Khoonsari; Andreas Tolf; Julia Steinmetz; Henrik Zetterberg; Torbjörn Åkerfeldt; Per-Johan Jakobsson; Anders Larsson; Ola Spjuth; Joachim Burman; Kim Kultima
Journal:  Theranostics       Date:  2018-08-07       Impact factor: 11.556

7.  Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing⁻Remitting Multiple Sclerosis.

Authors:  Stephanie Herman; Torbjörn Åkerfeldt; Ola Spjuth; Joachim Burman; Kim Kultima
Journal:  Cells       Date:  2019-01-24       Impact factor: 6.600

8.  Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis.

Authors:  Lara Kular; Maria Needhamsen; Milena Z Adzemovic; Tatiana Kramarova; David Gomez-Cabrero; Ewoud Ewing; Eliane Piket; Jesper Tegnér; Stephan Beck; Fredrik Piehl; Lou Brundin; Maja Jagodic
Journal:  Clin Epigenetics       Date:  2019-05-30       Impact factor: 6.551

9.  Methionine Diet Evoked Hyperhomocysteinemia Causes Hippocampal Alterations, Metabolomics Plasma Changes and Behavioral Pattern in Wild Type Rats.

Authors:  Maria Kovalska; Eva Baranovicova; Dagmar Kalenska; Anna Tomascova; Marian Adamkov; Libusa Kovalska; Jan Lehotsky
Journal:  Int J Mol Sci       Date:  2021-05-07       Impact factor: 5.923

10.  Conventional and Unconventional Therapeutic Strategies for Sialidosis Type I.

Authors:  Rosario Mosca; Diantha van de Vlekkert; Yvan Campos; Leigh E Fremuth; Jaclyn Cadaoas; Vish Koppaka; Emil Kakkis; Cynthia Tifft; Camilo Toro; Simona Allievi; Cinzia Gellera; Laura Canafoglia; Gepke Visser; Ida Annunziata; Alessandra d'Azzo
Journal:  J Clin Med       Date:  2020-03-04       Impact factor: 4.241
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