I-Te Lee1, Chen-Huan Chen2, Jun-Sing Wang3, Chia-Po Fu4, Wen-Jane Lee5, Kae-Woei Liang6, Shih-Yi Lin7, Wayne Huey-Herng Sheu8. 1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan. 2. Cardiovascular Research Center, National Yang-Ming University, Taipei 11221, Taiwan. 3. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. 4. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan. 5. Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan. 6. School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; Cardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan. 7. School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung 40705, Taiwan. 8. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan. Electronic address: whhsheu@vghtc.gov.tw.
Abstract
BACKGROUND: Arterial stiffening blunts postprandial vasodilatation. We hypothesized that brain-derived neurotrophic factor (BDNF) may modulate postprandial central pulse pressure, a surrogate marker for arterial stiffening. METHODS: A total of 82 non-diabetic subjects received a 75-g oral glucose tolerance test (OGTT) after overnight fasting. Serum BDNF concentrations were determined at 0, 30, and 120min to calculate the area under the curve (AUC). Brachial and central blood pressures were measured using a noninvasive central blood pressure monitor before blood withdrawals at 0 and 120min. RESULTS: With the median AUC of BDNF of 45(ng/ml)∗h as the cutoff value, the central pulse pressure after glucose intake was significantly higher in the subjects with a low BDNF than in those with a high BDNF (63±16 vs. 53±11mmHg, P=0.003), while the brachial pulse pressure was not significantly different between the 2 groups (P=0.099). In a multivariate linear regression model, a lower AUC of BDNF was an independent predictor of a higher central pulse pressure after oral glucose intake (linear regression coefficient-0.202, 95% confidence interval-0.340 to -0.065, P=0.004). CONCLUSION: After oral glucose challenge, a lower serum BDNF response is significantly associated with a higher central pulse pressure.
BACKGROUND: Arterial stiffening blunts postprandial vasodilatation. We hypothesized that brain-derived neurotrophic factor (BDNF) may modulate postprandial central pulse pressure, a surrogate marker for arterial stiffening. METHODS: A total of 82 non-diabetic subjects received a 75-g oral glucose tolerance test (OGTT) after overnight fasting. Serum BDNF concentrations were determined at 0, 30, and 120min to calculate the area under the curve (AUC). Brachial and central blood pressures were measured using a noninvasive central blood pressure monitor before blood withdrawals at 0 and 120min. RESULTS: With the median AUC of BDNF of 45(ng/ml)∗h as the cutoff value, the central pulse pressure after glucose intake was significantly higher in the subjects with a low BDNF than in those with a high BDNF (63±16 vs. 53±11mmHg, P=0.003), while the brachial pulse pressure was not significantly different between the 2 groups (P=0.099). In a multivariate linear regression model, a lower AUC of BDNF was an independent predictor of a higher central pulse pressure after oral glucose intake (linear regression coefficient-0.202, 95% confidence interval-0.340 to -0.065, P=0.004). CONCLUSION: After oral glucose challenge, a lower serum BDNF response is significantly associated with a higher central pulse pressure.