Literature DB >> 29080642

Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels?

Daniel D Bikle1, Sofie Malmstroem2, Janice Schwartz3.   

Abstract

The free hormone hypothesis postulates that only the nonbound fraction (the free fraction) of hormones that otherwise circulate in blood bound to their carrier proteins is able to enter cells and exert their biologic effects. For the vitamin D metabolites less than 1% (0.4% for 1,25(OH)2D and 0.03% for 25(OH)D) is free, with more than 99% bound to the vitamin D binding protein (DBP) and albumin (approximately 85% and 15%, respectively). Assays to measure the free vitamin D metabolite levels have been developed, and initial studies indicated their value in subjects with altered DBP levels. Published by Elsevier Inc.

Entities:  

Keywords:  Free hormone hypothesis; Free vitamin D; Liver disease; Pregnancy; Vitamin D; Vitamin D metabolism

Mesh：

Substances：

Year:  2017        PMID： 29080642      PMCID： PMC5675107          DOI： 10.1016/j.ecl.2017.07.013

Source DB:  PubMed          Journal:  Endocrinol Metab Clin North Am        ISSN： 0889-8529            Impact factor:   4.741


  69 in total

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Journal:  J Clin Endocrinol Metab       Date:  2015-08-27       Impact factor: 5.958

Review 2.  Variability in free 25(OH) vitamin D levels in clinical populations.

Authors:  J B Schwartz; J Lai; B Lizaola; L Kane; P Weyland; N A Terrault; N Stotland; D Bikle
Journal:  J Steroid Biochem Mol Biol       Date:  2013-11-15       Impact factor: 4.292

3.  An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.

Authors:  A Nykjaer; D Dragun; D Walther; H Vorum; C Jacobsen; J Herz; F Melsen; E I Christensen; T E Willnow
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4.  A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations.

Authors:  J B Schwartz; J Lai; B Lizaola; L Kane; S Markova; P Weyland; N A Terrault; N Stotland; D Bikle
Journal:  J Clin Endocrinol Metab       Date:  2014-01-31       Impact factor: 5.958

5.  Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene.

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Journal:  J Bone Miner Res       Date:  2007-02       Impact factor: 6.741

6.  Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease.

Authors:  D D Bikle; E Gee; B Halloran; J G Haddad
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8.  Osteoporosis in primary biliary cirrhosis: effects of 25-hydroxyvitamin D3 treatment.

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Review 9.  Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status?

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  41 in total

Review 1.  New developments in our understanding of vitamin metabolism, action and treatment.

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Review 2.  Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D.

Authors:  Christopher T Sempos; Annemieke C Heijboer; Daniel D Bikle; Jens Bollerslev; Roger Bouillon; Patsy M Brannon; Hector F DeLuca; Glenville Jones; Craig F Munns; John P Bilezikian; Andrea Giustina; Neil Binkley
Journal:  Br J Clin Pharmacol       Date:  2018-07-17       Impact factor: 4.335

3.  Relationship of Total and Free 25-Hydroxyvitamin D to Biomarkers and Metabolic Indices in Healthy Children.

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4.  Free vitamin D levels in steroid-sensitive nephrotic syndrome and healthy controls.

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5.  Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study in a multiracial cohort.

Authors:  Jin Xia; Yiqing Song; Shristi Rawal; Jing Wu; Stefanie N Hinkle; Michael Y Tsai; Cuilin Zhang
Journal:  Diabetes Obes Metab       Date:  2019-05-14       Impact factor: 6.577

Review 6.  The clinical relevance of native vitamin D in pediatric kidney disease.

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7.  Screening for Vitamin D Deficiency in Black Americans: Comparison of Total, Free, Bioavailable 25 Hydroxy Vitamin D Levels with Parathyroid Hormone Levels and Bone Mineral Density.

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8.  Total, Bioavailable, and Free 25(OH)D Relationship with Indices of Bone Health in Elderly: A Randomized Controlled Trial.

Authors:  Malak El Sabeh; Paola Ghanem; Laila Al-Shaar; Maya Rahme; Rafic Baddoura; Georges Halaby; Ravinder J Singh; Dirk Vanderschueren; Roger Bouillon; Ghada El-Hajj Fuleihan
Journal:  J Clin Endocrinol Metab       Date:  2021-01-23       Impact factor: 5.958

Review 9.  Vitamin D: Current Challenges between the Laboratory and Clinical Practice.

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10.  Low free 25-hydroxyvitamin D and high vitamin D binding protein and parathyroid hormone in obese Caucasians. A complex association with bone?

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