A K M Muraduzzaman1, Sharmin Sultana1, Tahmina Shirin2, Selina Khatun3, MdTarikul Islam4, Mahmudur Rahman5. 1. Department of Virology, Institute of Epidemiology, Disease Control & Research (IEDCR), Dhaka, Bangladesh. 2. Department of Virology, Institute of Epidemiology, Disease Control & Research (IEDCR), Dhaka, Bangladesh. Electronic address: tahmina.shirin14@gmail.com. 3. Department of Epidemiology, Institute of Epidemiology, Disease Control & Research (IEDCR), Dhaka, Bangladesh. 4. Laboratory of Genetics and Genomics, Institute for Developing Science and Health Initiatives, Dhaka, Bangladesh. 5. Institute of Epidemiology, Disease Control & Research (IEDCR), Dhaka, Bangladesh.
Abstract
OBJECTIVE: To explore the presence of Zika virus (ZIKV) in Bangladesh and to understand the associated risk factors. METHODS: A retrospective sero-surveillance was performed on stored serum samples of dengue surveillance conducted from 2013 to 2016. Real time RT-PCR was performed on randomly selected acute serum samples to detect the Zika virus nucleic acid. RESULTS: Of 200 samples screened, one was found positive for ZIKV by real time RT-PCR and further confirmed by genome sequencing. The case was a 65 years old male from a metropolitan city of Bangladesh who had no history of travel outside Bangladesh. Phylogenetic analysis of partial E gene sequences from Bangladeshi isolates demonstrated a close relationship with ZIKV from Brazil and current South American strains clustering within a monophyletic clade distinct from African lineage. CONCLUSIONS: Presence of ZIKV raises serious public health concerns in Bangladesh owing to its association with congenital anomalies/neurological-manifestations. We, therefore, recommend every suspected viral fever patient, particularly pregnant women be screened for ZIKV infection to rule out yet another emerging infection in Bangladesh.
OBJECTIVE: To explore the presence of Zika virus (ZIKV) in Bangladesh and to understand the associated risk factors. METHODS: A retrospective sero-surveillance was performed on stored serum samples of dengue surveillance conducted from 2013 to 2016. Real time RT-PCR was performed on randomly selected acute serum samples to detect the Zika virus nucleic acid. RESULTS: Of 200 samples screened, one was found positive for ZIKV by real time RT-PCR and further confirmed by genome sequencing. The case was a 65 years old male from a metropolitan city of Bangladesh who had no history of travel outside Bangladesh. Phylogenetic analysis of partial E gene sequences from Bangladeshi isolates demonstrated a close relationship with ZIKV from Brazil and current South American strains clustering within a monophyletic clade distinct from African lineage. CONCLUSIONS: Presence of ZIKV raises serious public health concerns in Bangladesh owing to its association with congenital anomalies/neurological-manifestations. We, therefore, recommend every suspected viral feverpatient, particularly pregnant women be screened for ZIKV infection to rule out yet another emerging infection in Bangladesh.
Authors: Corine H GeurtsvanKessel; Zhahirul Islam; Md Badrul Islam; Sandra Kamga; Nowshin Papri; David A M C van de Vijver; Chantal Reusken; Ramona Mogling; Astrid P Heikema; Israt Jahan; Florence K Pradel; Rebecca L Pavlicek; Quazi D Mohammad; Marion P G Koopmans; Bart C Jacobs; Hubert P Endtz Journal: Ann Clin Transl Neurol Date: 2018-04-06 Impact factor: 4.511