Xia Yang1, Wei Liu1,2, Allie Lyons1,3, Zaiwei Song1, Suodi Zhai1,2, Kai Hu4. 1. Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China. 2. Therapeutic Drug Monitoring and Clinical Toxicology Center, Peking University, Beijing, 100191, China. 3. College of Pharmacy, University of Kentucky, Lexington, KY, 40506, USA. 4. Department of Hematology, Peking University Third Hospital, Beijing, 100191, China. xiaohu7079@sina.com.
Abstract
BACKGROUND: The incidence of cytarabine-induced pericarditis is rare. So far, only a few cases have been reported worldwide. DESCRIPTION OF THE CASE: We are reporting a case of a 25-year-old male with acute myeloid leukemia (AML M2a) on chemotherapy who developed acute pericarditis after the administration of a cytarabine-containing regimen. The symptoms gradually improved after symptomatic treatment with steroids and other drugs. CONCLUSIONS: This case demonstrates that, although pericarditis induced by cytarabine is rare, early recognition of this potentially life-threatening complication and appropriate management will usually result in the patient's recovery.
BACKGROUND: The incidence of cytarabine-induced pericarditis is rare. So far, only a few cases have been reported worldwide. DESCRIPTION OF THE CASE: We are reporting a case of a 25-year-old male with acute myeloid leukemia (AML M2a) on chemotherapy who developed acute pericarditis after the administration of a cytarabine-containing regimen. The symptoms gradually improved after symptomatic treatment with steroids and other drugs. CONCLUSIONS: This case demonstrates that, although pericarditis induced by cytarabine is rare, early recognition of this potentially life-threatening complication and appropriate management will usually result in the patient's recovery.
Authors: Margaret R O'Donnell; Martin S Tallman; Camille N Abboud; Jessica K Altman; Frederick R Appelbaum; Daniel A Arber; Vijaya Bhatt; Dale Bixby; William Blum; Steven E Coutre; Marcos De Lima; Amir T Fathi; Melanie Fiorella; James M Foran; Steven D Gore; Aric C Hall; Patricia Kropf; Jeffrey Lancet; Lori J Maness; Guido Marcucci; Michael G Martin; Joseph O Moore; Rebecca Olin; Deniz Peker; Daniel A Pollyea; Keith Pratz; Farhad Ravandi; Paul J Shami; Richard M Stone; Stephen A Strickland; Eunice S Wang; Matthew Wieduwilt; Kristina Gregory; Ndiya Ogba Journal: J Natl Compr Canc Netw Date: 2017-07 Impact factor: 11.908