Literature DB >> 29079884

Modeling neurological diseases using iPSC-derived neural cells : iPSC modeling of neurological diseases.

Li Li1,2, Jianfei Chao1, Yanhong Shi3,4.   

Abstract

Developing efficient models for neurological diseases enables us to uncover disease mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the way of modeling human diseases, especially neurological diseases. Currently almost all types of neural cells, including but not limited to neural stem cells, neurons, astrocytes, oligodendrocytes and microglia, can be derived from iPSCs following developmental principles. These iPSC-derived neural cells provide valuable tools for studying neurological disease mechanisms, developing potential therapies, and deepening our understanding of the nervous system.

Entities:  

Keywords:  Disease modeling; Neurological diseases; iPSC

Mesh：

Year:  2017        PMID： 29079884      PMCID： PMC6029980          DOI： 10.1007/s00441-017-2713-x

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  78 in total

Review 1.  GFAP and its role in Alexander disease.

Authors:  Roy A Quinlan; Michael Brenner; James E Goldman; Albee Messing
Journal:  Exp Cell Res       Date:  2007-04-06       Impact factor: 3.905

2.  Directed differentiation of functional astroglial subtypes from human pluripotent stem cells.

Authors:  Robert Krencik; Su-Chun Zhang
Journal:  Nat Protoc       Date:  2011-10-13       Impact factor: 13.491

Review 3.  Physiology of microglia.

Authors:  Helmut Kettenmann; Uwe-Karsten Hanisch; Mami Noda; Alexei Verkhratsky
Journal:  Physiol Rev       Date:  2011-04       Impact factor: 37.312

4.  Efficient generation of astrocytes from human pluripotent stem cells in defined conditions.

Authors:  Atossa Shaltouki; Jun Peng; Qiuyue Liu; Mahendra S Rao; Xianmin Zeng
Journal:  Stem Cells       Date:  2013-05       Impact factor: 6.277

5.  Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.

Authors:  Zachary S Nevin; Daniel C Factor; Robert T Karl; Panagiotis Douvaras; Jeremy Laukka; Martha S Windrem; Steven A Goldman; Valentina Fossati; Grace M Hobson; Paul J Tesar
Journal:  Am J Hum Genet       Date:  2017-03-30       Impact factor: 11.025

6.  Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates.

Authors:  Qing Xu; Lihua Guo; Holly Moore; Ronald R Waclaw; Kenneth Campbell; Stewart A Anderson
Journal:  Neuron       Date:  2010-02-11       Impact factor: 17.173

Review 7.  Neuronal damage in brain inflammation.

Authors:  Orhan Aktas; Oliver Ullrich; Carmen Infante-Duarte; Robert Nitsch; Frauke Zipp
Journal:  Arch Neurol       Date:  2007-02

8.  Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons.

Authors:  Hong Chen; Kun Qian; Zhongwei Du; Jingyuan Cao; Andrew Petersen; Huisheng Liu; Lisle W Blackbourn; CindyTzu-Ling Huang; Anthony Errigo; Yingnan Yin; Jianfeng Lu; Melvin Ayala; Su-Chun Zhang
Journal:  Cell Stem Cell       Date:  2014-04-03       Impact factor: 24.633

9.  Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.

Authors:  Zhong-Wei Du; Hong Chen; Huisheng Liu; Jianfeng Lu; Kun Qian; CindyTzu-Ling Huang; Xiaofen Zhong; Frank Fan; Su-Chun Zhang
Journal:  Nat Commun       Date:  2015-03-25       Impact factor: 14.919

10.  Aberrant iPSC-derived human astrocytes in Alzheimer's disease.

Authors:  V C Jones; R Atkinson-Dell; A Verkhratsky; L Mohamet
Journal:  Cell Death Dis       Date:  2017-03-23       Impact factor: 8.469
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  19 in total

1.  Transcriptional profiling of isogenic Friedreich ataxia neurons and effect of an HDAC inhibitor on disease signatures.

Authors:  Jiun-I Lai; Daniel Nachun; Lina Petrosyan; Benjamin Throesch; Erica Campau; Fuying Gao; Kristin K Baldwin; Giovanni Coppola; Joel M Gottesfeld; Elisabetta Soragni
Journal:  J Biol Chem       Date:  2018-12-14       Impact factor: 5.157

Review 2.  Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics.

Authors:  Joseph A Fantuzzo; Ronald P Hart; Jeffrey D Zahn; Zhiping P Pang
Journal:  Dev Dyn       Date:  2018-09-12       Impact factor: 3.780

3.  GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease.

Authors:  Li Li; E Tian; Xianwei Chen; Jianfei Chao; Jeremy Klein; Qiuhao Qu; Guihua Sun; Guoqiang Sun; Yanzhou Huang; Charles D Warden; Peng Ye; Lizhao Feng; Xinqiang Li; Qi Cui; Abdullah Sultan; Panagiotis Douvaras; Valentina Fossati; Neville E Sanjana; Arthur D Riggs; Yanhong Shi
Journal:  Cell Stem Cell       Date:  2018-08-02       Impact factor: 24.633

4.  Neural stem cells: developmental mechanisms and disease modeling.

Authors:  Xinyu Zhao; Darcie L Moore
Journal:  Cell Tissue Res       Date:  2018-01       Impact factor: 5.249

5.  Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors.

Authors:  Saera Song; Archana Ashok; Damian Williams; Maria Kaufman; Karen Duff; Andrew Sproul
Journal:  Curr Protoc       Date:  2021-06

Review 6.  Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality.

Authors:  Daniel González-Nieto; Laura Fernández-García; José Pérez-Rigueiro; Gustavo V Guinea; Fivos Panetsos
Journal:  Polymers (Basel)       Date:  2018-02-13       Impact factor: 4.967

7.  TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling.

Authors:  Pauline Martin; Vilas Wagh; Surya A Reis; Serkan Erdin; Roberta L Beauchamp; Ghalib Shaikh; Michael Talkowski; Elizabeth Thiele; Steven D Sheridan; Stephen J Haggarty; Vijaya Ramesh
Journal:  Mol Autism       Date:  2020-01-06       Impact factor: 7.509

Review 8.  Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System.

Authors:  Mihyeon Bae; Hee-Gyeong Yi; Jinah Jang; Dong-Woo Cho
Journal:  Micromachines (Basel)       Date:  2020-09-16       Impact factor: 2.891

9.  Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.

Authors:  Kristina Xiao Liang; Cecilie Katrin Kristiansen; Sepideh Mostafavi; Guro Helén Vatne; Gina Alien Zantingh; Atefeh Kianian; Charalampos Tzoulis; Lena Elise Høyland; Mathias Ziegler; Roberto Megias Perez; Jessica Furriol; Zhuoyuan Zhang; Novin Balafkan; Yu Hong; Richard Siller; Gareth John Sullivan; Laurence A Bindoff
Journal:  EMBO Mol Med       Date:  2020-08-25       Impact factor: 12.137

10.  Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models.

Authors:  James A Gregory; Emily Hoelzli; Rawan Abdelaal; Catherine Braine; Miguel Cuevas; Madeline Halpern; Natalie Barretto; Nadine Schrode; Güney Akbalik; Kristy Kang; Esther Cheng; Kathryn Bowles; Steven Lotz; Susan Goderie; Celeste M Karch; Sally Temple; Alison Goate; Kristen J Brennand; Hemali Phatnani
Journal:  Cells       Date:  2020-06-05       Impact factor: 6.600
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