Yunjie Zhang1, Xianbiao Zou2, Hongxia Chen3, Yuguang Yang4, Hui Lin5, Xiaojuan Guo6. 1. Department of Dermatology of First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China. Electronic address: zhangyunjie25@sina.com. 2. Department of Dermatology of First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China. Electronic address: zouxianbiao25@sina.com. 3. Department of Dermatology of First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China. Electronic address: chenhongxia304@sina.com. 4. Department of Dermatology of First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China. Electronic address: yangyuguangpfk@163.com. 5. Department of Dermatology of First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China. Electronic address: linhui848538@sina.com. 6. Department of Dermatology of First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China. Electronic address: aihaoren66@tom.com.
Abstract
OBJECTIVE: To analyze the clinical efficacy of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating port-wine stains (PWS), and its clinical operation skills and operation essentials. METHOD: A total of 16 cases of PWS with negative HMME skin test results were included in this study. Their treated areas were exposed and injected with 5mg/kg HMME, and then irradiated under 532nm LED green light (produced by Wuhan YaGe LED1 modified machines), with the irradiation power density between 80 and 100mW/cm2. Each light spot was irradiated for 20-25min. After one treatment, the clinical efficacy and post-treatment reactions at each treated area were observed. RESULT: Under standard operation, two of the 16 cases were cured (12.5%) after one HMME-PDT treatment, eight cases indicates a good efficacy (50.0%), four cases showed alleviation (25.0%), while two cases displayed no efficacy (12.5%), indicating an one-time response rate of 87.5%. Pain was reported during treatment, and significant post-treatment edema was observed at the treated areas; And no allergy or other adverse reaction were reported. CONCLUSION: In adherence to operation standards and operation essentials during treatment, HMME-PDT shows a satisfactory clinical efficacy in treating PWS.
OBJECTIVE: To analyze the clinical efficacy of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating port-wine stains (PWS), and its clinical operation skills and operation essentials. METHOD: A total of 16 cases of PWS with negative HMME skin test results were included in this study. Their treated areas were exposed and injected with 5mg/kg HMME, and then irradiated under 532nm LED green light (produced by Wuhan YaGe LED1 modified machines), with the irradiation power density between 80 and 100mW/cm2. Each light spot was irradiated for 20-25min. After one treatment, the clinical efficacy and post-treatment reactions at each treated area were observed. RESULT: Under standard operation, two of the 16 cases were cured (12.5%) after one HMME-PDT treatment, eight cases indicates a good efficacy (50.0%), four cases showed alleviation (25.0%), while two cases displayed no efficacy (12.5%), indicating an one-time response rate of 87.5%. Pain was reported during treatment, and significant post-treatment edema was observed at the treated areas; And no allergy or other adverse reaction were reported. CONCLUSION: In adherence to operation standards and operation essentials during treatment, HMME-PDT shows a satisfactory clinical efficacy in treating PWS.
Authors: M Ingmar van Raath; Sandeep Chohan; Albert Wolkerstorfer; Chantal M A M van der Horst; Jacqueline Limpens; Xuan Huang; Baoyue Ding; Gert Storm; René R W J van der Hulst; Michal Heger Journal: PLoS One Date: 2020-07-02 Impact factor: 3.240
Authors: M Ingmar van Raath; Jojanneke E van Amesfoort; Martin Hermann; Yasin Ince; Maurice J Zwart; Agustina V Echague; Yan Chen; Baoyue Ding; Xuan Huang; Gert Storm; Michal Heger Journal: J Clin Transl Res Date: 2019-05-01