Literature DB >> 29076904

Potential Use of 18F-THK5351 PET to Identify Wallerian Degeneration of the Pyramidal Tract Caused by Cerebral Infarction.

Kenji Ishibashi1, Masashi Kameyama, Tetsuro Tago, Jun Toyohara, Kenji Ishii.   

Abstract

A 41-year-old man underwent F-THK5351 PET 2 years after a right middle cerebral artery infarction. F-THK5351 PET imaging revealed intense radioligand uptake along the ipsilateral pyramidal tract from the corona radiata to the medulla; intense uptake changed from the right side to the left side with descending axial sections at the level of the pyramidal decussation. F-THK5351 reportedly binds to monoamine oxidase B, which is highly expressed in astrocytes, suggesting that F-THK5351 concentrates in the lesion where gliosis occurs. Hence, in this case, F-THK5351 uptake may represent Wallerian degeneration accompanied with gliosis in the ipsilateral pyramidal tract.

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Year:  2017        PMID： 29076904     DOI： 10.1097/RLU.0000000000001868

Source DB:  PubMed          Journal:  Clin Nucl Med        ISSN： 0363-9762            Impact factor:   7.794


  6 in total

1.  Recurrent Lobar Hemorrhages and Multiple Cortical Superficial Siderosis in a Patient of Alzheimer's Disease With Homozygous APOE ε2 Allele Presenting Hypobetalipoproteinemia and Pathological Findings of 18F-THK5351 Positron Emission Tomography: A Case Report.

Authors:  Masaki Ikeda; Koichi Okamoto; Keiji Suzuki; Eriko Takai; Hiroo Kasahara; Natsumi Furuta; Minori Furuta; Yuichi Tashiro; Chisato Shimizu; Shin Takatama; Isao Naito; Mie Sato; Yasujiro Sakai; Manabu Takahashi; Masakuni Amari; Masamitsu Takatama; Tetsuya Higuchi; Yoshito Tsushima; Hideaki Yokoo; Masahiko Kurabayashi; Shun Ishibashi; Kenji Ishii; Yoshio Ikeda
Journal:  Front Neurol       Date:  2021-07-07       Impact factor: 4.003

Review 2.  Imaging of Reactive Astrogliosis by Positron Emission Tomography.

Authors:  Ryuichi Harada; Shozo Furumoto; Yukitsuka Kudo; Kazuhiko Yanai; Victor L Villemagne; Nobuyuki Okamura
Journal:  Front Neurosci       Date:  2022-02-08       Impact factor: 4.677

3.  Observation of the Effect of Nursing BPR on Thrombolytic Efficacy and Prognosis of Patients with Cerebral Infarction Based on CT Images.

Authors:  Shaomin Wang; Xiao Miao; Guanghui Zhang; Dandan Li; Li Xu
Journal:  Contrast Media Mol Imaging       Date:  2022-09-14       Impact factor: 3.009

4.  Visualization of ischemic stroke-related changes on 18F-THK-5351 positron emission tomography.

Authors:  Kuo-Lun Huang; Jung-Lung Hsu; Kun-Ju Lin; Chien-Hung Chang; Yi-Ming Wu; Ting-Yu Chang; Yeu-Jhy Chang; Chi-Hung Liu; Meng-Yang Ho; Shiaw-Pyng Wey; Tzu-Chen Yen; Nobuyuki Okamura; Ing-Tsung Hsiao; Tsong-Hai Lee
Journal:  EJNMMI Res       Date:  2018-07-16       Impact factor: 3.138

Review 5.  The development and validation of tau PET tracers: current status and future directions.

Authors:  Nobuyuki Okamura; Ryuichi Harada; Aiko Ishiki; Akio Kikuchi; Tadaho Nakamura; Yukitsuka Kudo
Journal:  Clin Transl Imaging       Date:  2018-07-20

6.  Rasagiline, a monoamine oxidase B inhibitor, reduces in vivo [18F]THK5351 uptake in progressive supranuclear palsy.

Authors:  Kok Pin Ng; Joseph Therriault; Min Su Kang; Hanne Struyfs; Tharick A Pascoal; Sulantha Mathotaarachchi; Monica Shin; Andrea L Benedet; Gassan Massarweh; Jean-Paul Soucy; Pedro Rosa-Neto; Serge Gauthier
Journal:  Neuroimage Clin       Date:  2019-11-13       Impact factor: 4.881
  6 in total

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