| Literature DB >> 29075984 |
Deepaneeta Sarmah1, Harpreet Kaur1, Jackson Saraf1, Kanta Pravalika1, Avirag Goswami2, Kiran Kalia1, Anupom Borah3, Xin Wang4, Kunjan R Dave2, Dileep R Yavagal2, Pallab Bhattacharya5,6.
Abstract
Stem cell therapy for ischemic stroke has widely been explored. Results from both preclinical and clinical studies have immensely supported the judicious use of stem cells as therapy. These provide an attractive means for preserving and replacing the damaged brain tissues following an ischemic attack. Since the past few years, researchers have used various types of stem cells to replenish insulted neuronal and glial cells in neurological disorders. In the present review, we discuss different types of stem cells employed for the treatment of ischemic stroke and mechanisms and challenges these cells face once introduced into the living system. Further, we also present different ways to maneuver and overcome challenges to translate the advances made at the preclinical level to clinics.Entities:
Keywords: Cell engineering; Clinical; Ischemic stroke; Neuroprotection; Preclinical; Stem cells
Mesh:
Year: 2017 PMID: 29075984 DOI: 10.1007/s12975-017-0580-0
Source DB: PubMed Journal: Transl Stroke Res ISSN: 1868-4483 Impact factor: 6.829