Literature DB >> 29075516

Correction to: pH of anti-VEGF agents in the human vitreous: low impact of very different formulations.

Bianka Sobolewska1, Peter Heiduschka2, Karl-Ulrich Bartz-Schmidt1, Focke Ziemssen1.   

Abstract

[This corrects the article DOI: 10.1186/s40942-017-0075-x.].

Entities:  

Year:  2017        PMID: 29075516      PMCID: PMC5644203          DOI: 10.1186/s40942-017-0097-4

Source DB:  PubMed          Journal:  Int J Retina Vitreous        ISSN: 2056-9920


Correction to: Int J Retin Vitr (2017) 3:22 DOI 10.1186/s40942-017-0075-x

After the publication of this article [1], we were made aware that the osmolarity of aflibercept (Eylea) was incorrect and should have been 286 mOsm and not 1000 mOsm. The correct version of Table 1 is shown in this correction (Table 1).
Table 1

The formulations and pH values of anti-VEGF agents

DrugConcentration (osmolarity)Dose in the vitreous (4 ml)/dose in 0.002 mlFormulationMeasured pH95% CI
Ranibizumab (Lucentis)10 mg/ml (289 mOsm)0.5 mg/0.02 mg10 mM histidine-HCl, 10% α,α-trehalose dihydrate, 0.01% polysorbate 205.325.0–5.63
Bevacizumab (Avastin)25 mg/ml (182 mOsm)1.25 mg/0.05 mg42 mM NaH2PO4·H2O, 8.45 mM Na2HPO4, 6% α,α-trehalose dihydrate, 0.04% polysorbate 205.915.63–6.19
Aflibercept (Eylea)40 mg/ml (286 mOsm)2 mg/0.08 mg10 mM Na3PO4, 40 mM NaCl, 5% sucrose, 0.03% polysorbate 206.055.78–6.31
Ziv-aflibercept (Zaltrap)25 mg/ml (1000 mOsm)1.25 mg/0.05 mg100 mM NaCl, 5 mM Na citrate, 5 mM Na3PO4, 20% sucrose, 0.1% polysorbate 206.16.05–6.15
Rituximab (Rituxan)10 mg/ml1 mg/0.02 mg154 mM NaCl, 25 mM Na citrate·2 H2O, 0.07% polysorbate 806.295.97–6.61
The formulations and pH values of anti-VEGF agents
  1 in total

1.  pH of anti-VEGF agents in the human vitreous: low impact of very different formulations.

Authors:  Bianka Sobolewska; Peter Heiduschka; Karl-Ulrich Bartz-Schmidt; Focke Ziemssen
Journal:  Int J Retina Vitreous       Date:  2017-06-26
  1 in total

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