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Literature DB >> 2907477

DNA rearrangement of a homeobox gene in myeloid leukaemic cells.

C Blatt¹, D Aberdam, R Schwartz, L Sachs.

Abstract

A homeobox gene rearrangement has been detected in WEHI-3B mouse myeloid leukaemic cells. The rearranged gene was identified as Hox-2.4 which is a member of the Hox-2 gene cluster on mouse chromosome 11. Both the normal and the rearranged genes were cloned and analysed, and the rearranged genomic Hox-2.4 gene was sequenced. The results indicate that the rearrangement is due to insertion of an intracisternal A particle 5' upstream to Hox-2.4 and that this resulted in constitutive expression of the homeobox gene. It is suggested that constitutive expression of the homeobox gene may interrupt the normal development program in these leukaemic cells.

Entities: Chemical

Mesh：

Substances：
DNA, Neoplasm

Year: 1988 PMID： 2907477 PMCID： PMC455142 DOI： 10.1002/j.1460-2075.1988.tb03326.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

55 in total

1. Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene.

Authors: R G Hawley; M J Shulman; N Hozumi
Journal: Mol Cell Biol Date: 1984-12 Impact factor: 4.272

2. A sequence conserved in both the chicken and mouse alpha 2(I) collagen promoter contains sites sensitive to S1 nuclease.

Authors: C McKeon; A Schmidt; B de Crombrugghe
Journal: J Biol Chem Date: 1984-05-25 Impact factor: 5.157

9. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.

Authors: K Monica; D P LeBrun; D A Dedera; R Brown; M L Cleary
Journal: Mol Cell Biol Date: 1994-12 Impact factor: 4.272

Review 10. The control of hematopoiesis and leukemia: from basic biology to the clinic.

Authors: L Sachs
Journal: Proc Natl Acad Sci U S A Date: 1996-05-14 Impact factor: 11.205

DNA rearrangement of a homeobox gene in myeloid leukaemic cells.

1. Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene.

2. A sequence conserved in both the chicken and mouse alpha 2(I) collagen promoter contains sites sensitive to S1 nuclease.

3. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans.

4. Lambda replacement vectors carrying polylinker sequences.

5. Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins.

6. Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI-3B is due to retroviral insertion near the gene.

7. Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.

8. Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins.

9. Segmental distribution of bithorax complex proteins during Drosophila development.

10. The location of Ultrabithorax transcripts in Drosophila tissue sections.

1. Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma.

2. A novel, plasmid-based system for studying gene rearrangements in mammalian cells.

3. HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

4. Functional heterogeneity of a large family of human LTR-like promoters and enhancers.

5. Coordinate regulation of HOX genes in human hematopoietic cells.

6. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins.

7. Isolation and analysis of chick homeobox cDNA clones.

8. Characterization of amplified intracisternal A-particle elements encoding integrase.

9. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.

Review 10. The control of hematopoiesis and leukemia: from basic biology to the clinic.