Giuseppe Pelosi1, Judith Cave2, Christian H Ottensmeier3. 1. Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy; Inter-hospital Pathology Division, Science & Technology Park, IRCCS MultiMedica, Via Gaudenzio Fantoli 16/15, 20138 Milan, Italy. Electronic address: giuseppe.pelosi@unimi.it. 2. Department of Medical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, UK. 3. Department of Medical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, UK; CRUK and NIHR Experimental Cancer Medicine Centre and Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.