Jason Zhang1, Sikarin Upala2, Anawin Sanguankeo3. 1. Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT. 2. Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY; Department of Preventive and Social Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.. Electronic address: Sikarin.Upala@bassett.org. 3. Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY; Department of Preventive and Social Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Abstract
OBJECTIVE: The purpose of this study was to evaluate the evidence for an association between diabetic retinopathy (DR) and vitamin D deficiency. DESIGN: Meta-analysis. METHODS: We included 14 observational studies with 10 007 participants who had undergone assessment for both DR and vitamin D deficiency. Pooled odds ratios (ORs) and 95% CIs were calculated using a random-effect, Mantel-Haenszel analysis. RESULTS: There was a statistically significant association between DR and vitamin D deficiency with an overall pooled OR of 1.27 (95% CI, 1.17-1.37; P = 0.001; I2 = 80%; Pheterogeneity = 0.01). There was also a statistically significant lower serum vitamin D level in patient subgroups with DR versus control groups, with an overall mean difference of -1.32 ng/mL (95% CI, -2.50 to -0.15; P = 0.001; I2 = 89%; Pheterogeneity = 0.01). CONCLUSION: There is a statistically significant association between vitamin D deficiency and DR.
OBJECTIVE: The purpose of this study was to evaluate the evidence for an association between diabetic retinopathy (DR) and vitamin D deficiency. DESIGN: Meta-analysis. METHODS: We included 14 observational studies with 10 007 participants who had undergone assessment for both DR and vitamin D deficiency. Pooled odds ratios (ORs) and 95% CIs were calculated using a random-effect, Mantel-Haenszel analysis. RESULTS: There was a statistically significant association between DR and vitamin D deficiency with an overall pooled OR of 1.27 (95% CI, 1.17-1.37; P = 0.001; I2 = 80%; Pheterogeneity = 0.01). There was also a statistically significant lower serum vitamin D level in patient subgroups with DR versus control groups, with an overall mean difference of -1.32 ng/mL (95% CI, -2.50 to -0.15; P = 0.001; I2 = 89%; Pheterogeneity = 0.01). CONCLUSION: There is a statistically significant association between vitamin D deficiency and DR.
Authors: Lina H M Ahmed; Alexandra E Butler; Soha R Dargham; Aishah Latif; Amal Robay; Omar M Chidiac; Amin Jayyousi; Jassim Al Suwaidi; Ronald G Crystal; Stephen L Atkin; Charbel Abi Khalil Journal: BMC Endocr Disord Date: 2020-05-15 Impact factor: 2.763