Gi-Shih Lien1,2, Ming-Shun Wu1,2, Chun-Nan Chen1, Chih-Wen Liu3, Fat-Moon Suk4,5. 1. Division of Gastroenterology, Department of Internal Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, No. 111, Section 3, Xing Long Road, Taipei, 116, Taiwan. 2. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 3. Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan. 4. Division of Gastroenterology, Department of Internal Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, No. 111, Section 3, Xing Long Road, Taipei, 116, Taiwan. fmsuk@tmu.edu.tw. 5. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. fmsuk@tmu.edu.tw.
Abstract
BACKGROUND AND STUDY AIM: Current capsule endoscopy procedures are ineffective for upper gastrointestinal (GI) tract examination because they do not allow for operator-controlled navigation of the capsule. External controllability of a capsule endoscope with an applied magnetic field is a possible solution to this problem. We developed a novel magnetic-assisted capsule endoscope (MACE) system to visualize the entire upper GI tract. The present study evaluated the safety and feasibility of the MACE system for the examination of the upper GI tract, including the esophagus, stomach, and duodenum. METHODS: The present open clinical study enrolled ten healthy volunteers. All participants swallowed a MACE, and an external magnetic field navigator was used for magnetic capsule manipulation in the upper GI tract. We assessed the maneuverability of the magnetic capsule and completeness of the MACE examination as well as the safety and tolerability of the procedure. RESULTS: The present study enrolled ten healthy volunteers with a mean age and body mass index of 47.7 years and 25.6 kg/m2, respectively. One volunteer withdrew because of difficulty in swallowing the capsule. In total, nine volunteers underwent the MACE examination. The average examination time was 27.1 min. The maneuverability of the capsule was assessed as good and fair in 55.6 and 44.4% of the participants, respectively. The overall completeness of the examination in the esophagus, stomach, and duodenum was 100, 85.2, and 86.1%, respectively. No severe adverse events occurred during this study. All participants exhibited satisfactory tolerance of the MACE examination. CONCLUSION: The MACE system has satisfactory maneuverability and visualization completeness with excellent acceptance and tolerance.
BACKGROUND AND STUDY AIM: Current capsule endoscopy procedures are ineffective for upper gastrointestinal (GI) tract examination because they do not allow for operator-controlled navigation of the capsule. External controllability of a capsule endoscope with an applied magnetic field is a possible solution to this problem. We developed a novel magnetic-assisted capsule endoscope (MACE) system to visualize the entire upper GI tract. The present study evaluated the safety and feasibility of the MACE system for the examination of the upper GI tract, including the esophagus, stomach, and duodenum. METHODS: The present open clinical study enrolled ten healthy volunteers. All participants swallowed a MACE, and an external magnetic field navigator was used for magnetic capsule manipulation in the upper GI tract. We assessed the maneuverability of the magnetic capsule and completeness of the MACE examination as well as the safety and tolerability of the procedure. RESULTS: The present study enrolled ten healthy volunteers with a mean age and body mass index of 47.7 years and 25.6 kg/m2, respectively. One volunteer withdrew because of difficulty in swallowing the capsule. In total, nine volunteers underwent the MACE examination. The average examination time was 27.1 min. The maneuverability of the capsule was assessed as good and fair in 55.6 and 44.4% of the participants, respectively. The overall completeness of the examination in the esophagus, stomach, and duodenum was 100, 85.2, and 86.1%, respectively. No severe adverse events occurred during this study. All participants exhibited satisfactory tolerance of the MACE examination. CONCLUSION: The MACE system has satisfactory maneuverability and visualization completeness with excellent acceptance and tolerance.
Authors: J F Rey; H Ogata; N Hosoe; K Ohtsuka; N Ogata; K Ikeda; H Aihara; I Pangtay; T Hibi; S Kudo; H Tajiri Journal: Endoscopy Date: 2010-06-30 Impact factor: 10.093
Authors: Jutta Keller; Christiane Fibbe; Frank Volke; Jeremy Gerber; Alexander C Mosse; Meike Reimann-Zawadzki; Elisha Rabinovitz; Peter Layer; Daniel Schmitt; Viola Andresen; Ulrich Rosien; Paul Swain Journal: Gastrointest Endosc Date: 2010-11-09 Impact factor: 9.427
Authors: Paul Swain; Arifa Toor; Frank Volke; Jutta Keller; Jeremy Gerber; Elisha Rabinovitz; Richard I Rothstein Journal: Gastrointest Endosc Date: 2010-04-24 Impact factor: 9.427