BACKGROUND/AIMS: To report a case and the histopathology of uveal melanoma cell seeding following transretinal tumor biopsy for a suspected uveal lesion. METHODS: Interventional case report. RESULTS: A 66-year-old male presented with a pigmented perilimbal episcleral lesion overlying an intraocular mass at the pars plana, 3.5 years after transretinal biopsy and ruthenium plaque brachytherapy for a choroidal melanoma at the posterior pole. The patient underwent enucleation of the eye. Histopathology confirmed a recurrence of uveal melanoma with intra- and extrascleral tumor portions. Serial sections revealed the posterior border of this newfound pars plana melanoma separated from the radiation scar by a viable and tumor-free choroidal area, thus failing to establish a continuity between secondary and primary tumor. CONCLUSION: Transretinal tumor biopsy is of high diagnostic and prognostic value in the management of uveal lesions, but also bears the potential risk for tumor cell seeding.
BACKGROUND/AIMS: To report a case and the histopathology of uveal melanoma cell seeding following transretinal tumor biopsy for a suspected uveal lesion. METHODS: Interventional case report. RESULTS: A 66-year-old male presented with a pigmented perilimbal episcleral lesion overlying an intraocular mass at the pars plana, 3.5 years after transretinal biopsy and ruthenium plaque brachytherapy for a choroidal melanoma at the posterior pole. The patient underwent enucleation of the eye. Histopathology confirmed a recurrence of uveal melanoma with intra- and extrascleral tumor portions. Serial sections revealed the posterior border of this newfound pars plana melanoma separated from the radiation scar by a viable and tumor-free choroidal area, thus failing to establish a continuity between secondary and primary tumor. CONCLUSION:Transretinal tumor biopsy is of high diagnostic and prognostic value in the management of uveal lesions, but also bears the potential risk for tumor cell seeding.
Authors: Arun D Singh; Carlos A Medina; Nakul Singh; Mary E Aronow; Charles V Biscotti; Pierre L Triozzi Journal: Br J Ophthalmol Date: 2015-07-31 Impact factor: 4.638
Authors: Ludwig M Heindl; Tanja N Hofmann; Werner Adler; Harald L J Knorr; Leonard M Holbach; Gottfried O H Naumann; Friedrich E Kruse; Claus Cursiefen Journal: Ophthalmology Date: 2009-11-04 Impact factor: 12.079
Authors: Amy C Schefler; Daniel Gologorsky; Brian P Marr; Carol L Shields; Ignacio Zeolite; David H Abramson Journal: JAMA Ophthalmol Date: 2013-09 Impact factor: 7.389
Authors: Catherine D Van Raamsdonk; Vladimir Bezrookove; Gary Green; Jürgen Bauer; Lona Gaugler; Joan M O'Brien; Elizabeth M Simpson; Gregory S Barsh; Boris C Bastian Journal: Nature Date: 2008-12-10 Impact factor: 49.962