| Literature DB >> 29069336 |
Sandy S Pineda1, Pierre-Alain Chaumeil1,2, Anne Kunert1,2, Quentin Kaas1, Mike W C Thang1,2, Lien Le3, Michael Nuhn3, Volker Herzig1, Natalie J Saez1, Ben Cristofori-Armstrong1, Raveendra Anangi1, Sebastian Senff1, Dominique Gorse1,2, Glenn F King1.
Abstract
Summary: ArachnoServer is a manually curated database that consolidates information on the sequence, structure, function and pharmacology of spider-venom toxins. Although spider venoms are complex chemical arsenals, the primary constituents are small disulfide-bridged peptides that target neuronal ion channels and receptors. Due to their high potency and selectivity, these peptides have been developed as pharmacological tools, bioinsecticides and drug leads. A new version of ArachnoServer (v3.0) has been developed that includes a bioinformatics pipeline for automated detection and analysis of peptide toxin transcripts in assembled venom-gland transcriptomes. ArachnoServer v3.0 was updated with the latest sequence, structure and functional data, the search-by-mass feature has been enhanced, and toxin cards provide additional information about each mature toxin. Availability and implementation: http://arachnoserver.org. Contact: support@arachnoserver.org. Supplementary information: Supplementary data are available at Bioinformatics online.Entities:
Mesh：
Substances：
Year: 2018 PMID： 29069336 DOI： 10.1093/bioinformatics/btx661
Source DB: PubMed Journal: Bioinformatics ISSN： 1367-4803 Impact factor: 6.937