Literature DB >> 29068139

Comparative study on chemical components and anti-inflammatory effects of Panax notoginseng flower extracted by water and methanol.

Li-Juan Ma1, Fang Liu1, Zhang-Feng Zhong1, Jian-Bo Wan1.   

Abstract

Methanol and water are commonly used solvents for chemical analysis and traditional decoction, respectively. In the present study, a high-performance liquid chromatography with ultraviolet detection method was developed to quantify 11 saponins in Panax notoginseng flower extracted by aqueous solution and methanol, and chemical components and anti-inflammatory effects of these two extracts were compared. The separation of 11 saponins, including notoginsenoside Fc and ginsenoside Rc, was well achieved on a Zorbax SB C18 column. This developed method provides an adequate linearity (r2  > 0.999), repeatability (RSD < 4.26%), inter- and intraday variations (RSD < 3.20%) with recovery (94.7-104.1%) of 11 saponins concerned. Our data indicated that ginsenoside biotransformation in PNF was found, when water was used as the extraction solvent, but not methanol. Specifically, the major components of Panax notoginseng flower, ginsenosides Rb1, Rc, Rb2, Rb3, and Rd, can be near completely transformed to the minor components, gypenoside XVII, notoginsenoside Fe, ginsenoside Rd2, notoginsenoside Fd, and ginsenoside F2, respectively. Total protein isolated from Panax notoginseng flower is responsible for this ginsenoside biotransformation. Additionally, methanol extract exerted the stronger anti-inflammatory effects than water extract in lipopolysaccharide-induced RAW264.7 cells. This difference in anti-inflammatory action might be attributed to their chemical difference of saponins.
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Panax notoginseng flower; anti-inflammation; ginsenoside biotransformation; traditional Chinese medicine

Mesh:

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Year:  2017        PMID: 29068139     DOI: 10.1002/jssc.201700641

Source DB:  PubMed          Journal:  J Sep Sci        ISSN: 1615-9306            Impact factor:   3.645


  5 in total

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Authors:  Yaohui Wang; Long Li; Gege Cheng; Lanfu Li; Xiuyu Liu; Qin Huang
Journal:  Polymers (Basel)       Date:  2022-06-14       Impact factor: 4.967

2.  Preparation of Rosin-Based Composite Membranes and Study of Their Dencichine Adsorption Properties.

Authors:  Long Li; Xiuyu Liu; Lanfu Li; Sentao Wei; Qin Huang
Journal:  Polymers (Basel)       Date:  2022-05-26       Impact factor: 4.967

3.  Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy.

Authors:  Jingjing Liu; Chunyu Jiang; Xu Ma; Lishuai Feng; Jianbo Wang
Journal:  J Diabetes Res       Date:  2019-09-03       Impact factor: 4.011

4.  Production of Minor Ginsenosides from Panax notoginseng Flowers by Cladosporium xylophilum.

Authors:  Yin-Fei Li; Ying-Zhong Liang; Xiu-Ming Cui; Lin-Jiao Shao; Deng-Ji Lou; Xiao-Yan Yang
Journal:  Molecules       Date:  2022-10-05       Impact factor: 4.927

5.  Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng.

Authors:  Guangfei Wei; Feng Yang; Fugang Wei; Lianjuan Zhang; Ying Gao; Jun Qian; Zhongjian Chen; Zhengwei Jia; Yong Wang; He Su; Linlin Dong; Jiang Xu; Shilin Chen
Journal:  J Ginseng Res       Date:  2019-05-29       Impact factor: 6.060

  5 in total

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