Satoshi Funada1, Takahisa Kawaguchi2, Naoki Terada1, Hiromitsu Negoro1, Yasuharu Tabara2, Shinji Kosugi3, Ryo Yamada2, Takeo Nakayama4, Shusuke Akamatsu1, Koji Yoshimura5, Fumihiko Matsuda2, Osamu Ogawa6. 1. Department of Urology, Kyoto University Hospital, Kyoto, Japan. 2. Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. 3. Department of Medical Ethics and Medical Genetics, Kyoto University School of Public Health, Kyoto, Japan. 4. Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan. 5. Department of Urology, Shizuoka General Hospital, Shizuoka, Japan. 6. Department of Urology, Kyoto University Hospital, Kyoto, Japan. Electronic address: ogawao@kuhp.kyoto-u.ac.jp.
Abstract
PURPOSE: The prevalence of overactive bladder is increasing globally. It has a substantial impact on quality of life and represents a heavy economic burden. We evaluated the prevalence of overactive bladder in a Japanese population and analyzed whether genetic and environmental factors influence overactive bladder. MATERIALS AND METHODS: This cross-sectional study was performed as part of the Nagahama cohort project. It comprised a questionnaire survey as well as anthropometric, physiological and biochemical measures, and genomic information on participants 30 to 74 years old in Nagahama, Japan. A genome-wide association study was performed in 4,645 participants, including 1,521 men and 3,124 women, using 99,059 single nucleotide polymorphisms. Univariate and multivariable logistic regression was done to analyze environmental factors associated with overactive bladder. RESULTS: The prevalence of overactive bladder was 11.8%, including 15.3% in men and 10.1% in women, and it increased with age. We found no significant association between overactive bladder and any single nucleotide polymorphism in the genome-wide association study. However, in the multivariable logistic regression model overactive bladder was positively associated with environmental factors, including age, depression and the consumption of cake or Japanese confection. CONCLUSIONS: The prevalence of overactive bladder was greater in men than in women, especially among the elderly. Environmental factors rather than genetic variants more likely contribute to overactive bladder.
PURPOSE: The prevalence of overactive bladder is increasing globally. It has a substantial impact on quality of life and represents a heavy economic burden. We evaluated the prevalence of overactive bladder in a Japanese population and analyzed whether genetic and environmental factors influence overactive bladder. MATERIALS AND METHODS: This cross-sectional study was performed as part of the Nagahama cohort project. It comprised a questionnaire survey as well as anthropometric, physiological and biochemical measures, and genomic information on participants 30 to 74 years old in Nagahama, Japan. A genome-wide association study was performed in 4,645 participants, including 1,521 men and 3,124 women, using 99,059 single nucleotide polymorphisms. Univariate and multivariable logistic regression was done to analyze environmental factors associated with overactive bladder. RESULTS: The prevalence of overactive bladder was 11.8%, including 15.3% in men and 10.1% in women, and it increased with age. We found no significant association between overactive bladder and any single nucleotide polymorphism in the genome-wide association study. However, in the multivariable logistic regression model overactive bladder was positively associated with environmental factors, including age, depression and the consumption of cake or Japanese confection. CONCLUSIONS: The prevalence of overactive bladder was greater in men than in women, especially among the elderly. Environmental factors rather than genetic variants more likely contribute to overactive bladder.
Authors: Wilke M Post; Alejandra M Ruiz-Zapata; Hilde Grens; Rob B M de Vries; Geert Poelmans; Marieke J H Coenen; Dick A W Janssen; John P F A Heesakkers; Egbert Oosterwijk; Kirsten B Kluivers Journal: Neurourol Urodyn Date: 2020-09-19 Impact factor: 2.696
Authors: Ghazi Al Edwan; Mohamed S Abdelazim; Salim E Salhab; Yousfi M Jamal; Mohamed A Soliman Journal: Adv Ther Date: 2020-12-22 Impact factor: 3.845