Liana O Ventura1, Linda Lawrence2, Camila V Ventura1, Gordon N Dutton3, Polyana Marinho4, Priscila F Ferro4, Adriana L Gois1, Natalia C Dias4, Larissa Ventura4, Cynthia A Moore5, Lea Hyvärinen6. 1. Department of Ophthalmology, Altino Ventura Foundation (FAV), Recife, PE, Brazil; Department of Ophthalmology, HOPE Eye Hospital, Recife, PE, Brazil. 2. Private Ophthalmology practice, Salina, Kansas. Electronic address: lmlawrencemd@gmail.com. 3. Department of Optometry and Visual Science, Glasgow Caledonian University, Glasgow, United Kingdom. 4. Department of Ophthalmology, Altino Ventura Foundation (FAV), Recife, PE, Brazil. 5. National Office of Public Health Genomics Centers for Disease Control and Prevention, Atlanta, Georgia. 6. Faculty of Rehabilitation Sciences, University of Dortmund, Germany.
Abstract
PURPOSE: To describe the immediate response to correction of refractive errors and hypoaccommodation in children with congenital Zika syndrome (CZS). METHODS: Children born between May and December 2015 with a confirmed diagnosis of CZS and enrolled in a multidisciplinary early intervention program were included in this study. All children received a comprehensive ophthalmic examination, including dynamic retinoscopy and cycloplegic refraction. Children were prescribed their full correction if they met the criteria for refractive error, and additional plus 3.00 overcorrection for strabismus, accommodative dysfunction, and/or low vision. Monocular and binocular visual responses to Lea Grating Test at 30 cm, with and without eyeglasses, were measured on day 1 of glasses wear. RESULTS: A total of 60 children were evaluated (mean age at evaluation, 11.5 ± 1.1 months; range, 9.0-16.0 months). Lea Grating Test responses were abnormal in all children prior to spectacle correction. Hypoaccommodation was present in 17 of 21 children (81%). Overcorrection was prescribed for all children. Visual responses were subnormal even with glasses use; however, immediate improvement in binocular vision was found in 37 children (62%) and in 74 of 119 eyes (62.2%). For the monocular visual improvement, 27 of 115 eyes (23.5%) had structural abnormalities, and 44 of 115 eyes (38.3%) were structurally normal. There was a statistical difference between the cycloplegic refraction of the children in August and in November, including emmetropia (P = 0.001), hyperopia (P = 0.000), myopia (P = 0.007), and astigmatism (P = 0.004). CONCLUSIONS: Eyeglasses can improve visual acuity in children with CZS. Significant changes in their refractive status over time requires periodic updates.
PURPOSE: To describe the immediate response to correction of refractive errors and hypoaccommodation in children with congenital Zika syndrome (CZS). METHODS:Children born between May and December 2015 with a confirmed diagnosis of CZS and enrolled in a multidisciplinary early intervention program were included in this study. All children received a comprehensive ophthalmic examination, including dynamic retinoscopy and cycloplegic refraction. Children were prescribed their full correction if they met the criteria for refractive error, and additional plus 3.00 overcorrection for strabismus, accommodative dysfunction, and/or low vision. Monocular and binocular visual responses to Lea Grating Test at 30 cm, with and without eyeglasses, were measured on day 1 of glasses wear. RESULTS: A total of 60 children were evaluated (mean age at evaluation, 11.5 ± 1.1 months; range, 9.0-16.0 months). Lea Grating Test responses were abnormal in all children prior to spectacle correction. Hypoaccommodation was present in 17 of 21 children (81%). Overcorrection was prescribed for all children. Visual responses were subnormal even with glasses use; however, immediate improvement in binocular vision was found in 37 children (62%) and in 74 of 119 eyes (62.2%). For the monocular visual improvement, 27 of 115 eyes (23.5%) had structural abnormalities, and 44 of 115 eyes (38.3%) were structurally normal. There was a statistical difference between the cycloplegic refraction of the children in August and in November, including emmetropia (P = 0.001), hyperopia (P = 0.000), myopia (P = 0.007), and astigmatism (P = 0.004). CONCLUSIONS: Eyeglasses can improve visual acuity in children with CZS. Significant changes in their refractive status over time requires periodic updates.
Authors: Marion E Rice; Romeo R Galang; Nicole M Roth; Sascha R Ellington; Cynthia A Moore; Miguel Valencia-Prado; Esther M Ellis; Aifili John Tufa; Livinson A Taulung; Julia M Alfred; Janice Pérez-Padilla; Camille A Delgado-López; Sherif R Zaki; Sarah Reagan-Steiner; Julu Bhatnagar; John F Nahabedian; Megan R Reynolds; Marshalyn Yeargin-Allsopp; Laura J Viens; Samantha M Olson; Abbey M Jones; Madelyn A Baez-Santiago; Philip Oppong-Twene; Kelley VanMaldeghem; Elizabeth L Simon; Jazmyn T Moore; Kara D Polen; Braeanna Hillman; Ruta Ropeti; Leishla Nieves-Ferrer; Mariam Marcano-Huertas; Carolee A Masao; Edlen J Anzures; Ransen L Hansen; Stephany I Pérez-Gonzalez; Carla P Espinet-Crespo; Mildred Luciano-Román; Carrie K Shapiro-Mendoza; Suzanne M Gilboa; Margaret A Honein Journal: MMWR Morb Mortal Wkly Rep Date: 2018-08-10 Impact factor: 17.586
Authors: Lavínia Schuler-Faccini; Miguel Del Campo; Alfredo García-Alix; Liana O Ventura; Juliano André Boquett; Vanessa van der Linden; André Pessoa; Hélio van der Linden Júnior; Camila V Ventura; Mariana Carvalho Leal; Thayne Woycinck Kowalski; Lais Rodrigues Gerzson; Carla Skilhan de Almeida; Lucélia Santi; Walter O Beys-da-Silva; André Quincozes-Santos; Jorge A Guimarães; Patricia P Garcez; Julia do Amaral Gomes; Fernanda Sales Luiz Vianna; André Anjos da Silva; Lucas Rosa Fraga; Maria Teresa Vieira Sanseverino; Alysson R Muotri; Rafael Lopes da Rosa; Alberto Mantovani Abeche; Clairton Marcolongo-Pereira; Diogo O Souza Journal: Front Genet Date: 2022-03-08 Impact factor: 4.599