Literature DB >> 2906613

Evidence for non-adrenergic binding sites for [3H]idazoxan in the smooth muscle of rabbit urethra.

F Yablonsky1, J P Riffaud, J Y Lacolle, J P Dausse.   

Abstract

The binding characteristics of [3H]idazoxan and [3H]rauwolscine, two potent alpha 2-adrenoceptor antagonists, were compared in the rabbit urethral smooth muscle. The maximal binding capacity was 6 times higher for [3H]idazoxan than for [3H]rauwolscine in male rabbits. No difference was observed for these radioligands in female rabbits. There were marked differences in the ability of alpha 2-adrenergic compounds to inhibit [3H]idazoxan and [3H]rauwolscine binding. These results were consistent with the existence of non-alpha 2-adrenoceptor sites for [3H]idazoxan in the rabbit urethral smooth muscle.

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Year:  1988        PMID： 2906613     DOI： 10.1016/0014-2999(88)90100-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

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Authors:  G J Molderings; F Hentrich; M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-12       Impact factor: 3.000

2.  [3H]-idazoxan binds with high affinity to two sites on hamster adipocytes: an alpha 2-adrenoceptor and a non-adrenoceptor site.

Authors:  A C MacKinnon; C M Brown; M Spedding; A T Kilpatrick
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

3.  [3H]-idazoxan binding to rabbit cerebral cortex recognises multiple imidazoline I2-type receptors: pharmacological characterization and relationship to monoamine oxidase.

Authors:  A Renouard; P S Widdowson; A Cordi
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

4.  Species-selective binding of [3H]-idazoxan to alpha 2-adrenoceptors and non-adrenoceptor, imidazoline binding sites in the central nervous system.

Authors:  J F Hussain; D A Kendall; V G Wilson
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

5.  Relevance of the use of [3H]-clonidine to identify imidazoline receptors in the rabbit brainstem.

Authors:  G Bricca; J Zhang; H Greney; M Dontenwill; J Stutzmann; A Belcourt; P Bousquet
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

6.  The pharmacology of RS-15385-197, a potent and selective alpha 2-adrenoceptor antagonist.

Authors:  C M Brown; A C MacKinnon; W S Redfern; P E Hicks; A T Kilpatrick; C Small; M Ramcharan; R U Clague; R D Clark; C B MacFarlane
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

7.  Alpha 2-adrenoceptor subtypes and imidazoline-like binding sites in the rat brain.

Authors:  C M Brown; A C MacKinnon; J C McGrath; M Spedding; A T Kilpatrick
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739
  7 in total

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