Chuanbo Xie1, Wei Wang2, Xiuhong Li3, Nan Shao4, Weidong Li5. 1. a Department of Cancer Prevention Research, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China , Sun Yat-sen University Cancer Center , Guangzhou , China. 2. b Department of Thoracic Surgery , the Second Affiliated Hospital of Guangzhou Medical University , Guangzhou , China. 3. c Department of Maternal and Child Health, School of Public Health , Sun Yat-Sen University , Guangzhou , China. 4. d Breast Disease Center , the First Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China. 5. e Division of Birth Cohort Study , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
Abstract
OBJECTIVE: The association between gestational diabetes mellitus (GDM) and maternal breast cancer risk was controversial and inclusive. In this study, we aimed to examine the association between GDM and maternal breast cancer using meta-analysis method. METHODS: Researchers searched and reviewed the topic related articles comprehensively. For each eligible article, we extracted the effect size (odds ratio/relative risk or OR/RR) and its 95% confidence interval (CI). We used random effect models to combine the effect sizes. Subgroups analysis were used to examine whether the effects of GDM on breast cancer risk differed across GDM ascertainment methods, breast cancer ascertainment method, risk of bias, and country of study origin. RESULTS: Five case-control studies and six cohort studies which met the eligible criteria were included into analysis. Overall, we didn't find significant associations between GDM and breast cancer among case-control studies (pooled OR = 0.85, 95%CI = 0.65, 1.10) and cohort studies pooled RR = 1.00, 95%CI = 0.80, 1.25). However, our subgroup analysis showed that GDM was a protective factor for breast cancer among the case-control studies in which breast cancer was ascertained via cancer registry system (OR = 0.73, 95%CI = 0.54, 1.00). CONCLUSIONS: GDM during pregnancy is not associated with breast cancer in our study, suggesting that GDM mothers are not needed to be too anxious about their future breast cancer risk.
OBJECTIVE: The association between gestational diabetes mellitus (GDM) and maternal breast cancer risk was controversial and inclusive. In this study, we aimed to examine the association between GDM and maternal breast cancer using meta-analysis method. METHODS: Researchers searched and reviewed the topic related articles comprehensively. For each eligible article, we extracted the effect size (odds ratio/relative risk or OR/RR) and its 95% confidence interval (CI). We used random effect models to combine the effect sizes. Subgroups analysis were used to examine whether the effects of GDM on breast cancer risk differed across GDM ascertainment methods, breast cancer ascertainment method, risk of bias, and country of study origin. RESULTS: Five case-control studies and six cohort studies which met the eligible criteria were included into analysis. Overall, we didn't find significant associations between GDM and breast cancer among case-control studies (pooled OR = 0.85, 95%CI = 0.65, 1.10) and cohort studies pooled RR = 1.00, 95%CI = 0.80, 1.25). However, our subgroup analysis showed that GDM was a protective factor for breast cancer among the case-control studies in which breast cancer was ascertained via cancer registry system (OR = 0.73, 95%CI = 0.54, 1.00). CONCLUSIONS: GDM during pregnancy is not associated with breast cancer in our study, suggesting that GDM mothers are not needed to be too anxious about their future breast cancer risk.
Entities:
Keywords:
Gestational diabetes mellitus; breast cancer; meta-analysis
Authors: Kimberly A Bertrand; Katie M O'Brien; Lauren B Wright; Julie R Palmer; William J Blot; A Heather Eliassen; Lynn Rosenberg; Sven Sandin; Deirdre Tobias; Elisabete Weiderpass; Wei Zheng; Anthony J Swerdlow; Minouk J Schoemaker; Hazel B Nichols; Dale P Sandler Journal: Int J Epidemiol Date: 2022-01-06 Impact factor: 7.196
Authors: Kimberly A Bertrand; Katie M O'Brien; Lauren B Wright; Julie R Palmer; William J Blot; A Heather Eliassen; Lynn Rosenberg; Sven Sandin; Deirdre Tobias; Elisabete Weiderpass; Wei Zheng; Anthony J Swerdlow; Minouk J Schoemaker; Hazel B Nichols; Dale P Sandler Journal: Int J Epidemiol Date: 2022-01-06 Impact factor: 9.685