| Literature DB >> 29065723 |
Maryam Ghasemi1,2, Effat Alizadeh1,2, Khatereh Saei Arezoumand2, Behzad Fallahi Motlagh3, Nosratollah Zarghami1,2,4.
Abstract
The intraocular administration of the ciliary neurotrophic factor (CNTF) has been found to attenuate the photoreceptor degeneration and preserve retinal functions in the animal research models of the inherited or induced retinal disease. Studies with the aim of CNTF transfer to the posterior segment inside the eye have been directed to determine the best method for its administration. An ideal delivery method would overcome the eye drug elimination mechanisms or barriers and provide the sustained release of the CNTF into retina in the safest fashion with the minimum harm to the quality of life. This review focuses on the present state of CNTF delivery to retina, also provides an overview of available technologies and their challenges.Entities:
Keywords: CNTF; delivery; encapsulated cell technology; retina; viral vectors
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Year: 2017 PMID： 29065723 DOI： 10.1080/21691401.2017.1391820
Source DB: PubMed Journal: Artif Cells Nanomed Biotechnol ISSN： 2169-1401 Impact factor: 5.678