Hasan Nahouli1, Nour El Arnaout2, Elias Chalhoub3, Elie Anastadiadis4, Hiba El Hajj5. 1. 1 Faculty of Medicine, American University of Beirut , Beirut, Lebanon . 2. 2 Global Health Institute, American University of Beirut , Beirut, Lebanon . 3. 3 Faculty of Health Sciences, University of Balamand , Beirut, Lebanon . 4. 4 Faculty of Medicine, University of Balamand , Beirut, Lebanon . 5. 5 Department of Internal Medicine/Experimental Pathology, Immunology and Microbiology, American University of Beirut , Beirut, Lebanon .
Abstract
OBJECTIVE: Toxoplasma gondii, the causative agent of toxoplasmosis, is a zoonotic obligate intracellular protozoan parasite responsible for the infection of almost one-third of the world's population. T. gondii is particularly threatening for primo-infected pregnant women and may lead, following vertical transplacental transmission, to spontaneous abortion, miscarriage, or severe manifestations in the newborn. The aim of this study was to provide an updated estimate of the seroprevalence of anti-T. gondii antibodies among a group of Lebanese pregnant women and its seroconversion rate. METHODS: This is a retrospective cohort study, in which medical records of 11,000 pregnant women were screened. These women visited a private Obstetrics and Gynecology clinic located in Beirut, the capital of Lebanon, during the period of January 1994 till September 2015. Serological results of anti-T. gondii immunoglobulin G (IgG) and immunoglobulin M (IgM) results of 2456 Lebanese pregnant women who fulfilled the inclusion criteria were included in the analysis. Seropositivity and seroconversion rates for women with repeated tests were reported according to age and area of residence. RESULTS: The overall anti-T. gondii IgG and IgM seropositivity among 2456 Lebanese pregnant women was 82.6% and 1.8% respectively. The highest IgG seropositivity is among the age group of 35-44 years (87.81%) and at the governorate of "Mount Lebanon" (82.95%). Sixty-four seroconversions were detected and two abortions due to T. gondii infection during pregnancy were recorded. CONCLUSIONS: The seroprevalence of anti-T. gondii IgG among the screened pregnant women in Lebanon is the highest in the Arab region. These results highlight the importance of running a national sample survey to estimate the real potential burden of this infection and its impact on maternal and fetal health.
OBJECTIVE: Toxoplasma gondii, the causative agent of toxoplasmosis, is a zoonotic obligate intracellular protozoan parasite responsible for the infection of almost one-third of the world's population. T. gondii is particularly threatening for primo-infected pregnant women and may lead, following vertical transplacental transmission, to spontaneous abortion, miscarriage, or severe manifestations in the newborn. The aim of this study was to provide an updated estimate of the seroprevalence of anti-T. gondii antibodies among a group of Lebanese pregnant women and its seroconversion rate. METHODS: This is a retrospective cohort study, in which medical records of 11,000 pregnant women were screened. These women visited a private Obstetrics and Gynecology clinic located in Beirut, the capital of Lebanon, during the period of January 1994 till September 2015. Serological results of anti-T. gondii immunoglobulin G (IgG) and immunoglobulin M (IgM) results of 2456 Lebanese pregnant women who fulfilled the inclusion criteria were included in the analysis. Seropositivity and seroconversion rates for women with repeated tests were reported according to age and area of residence. RESULTS: The overall anti-T. gondii IgG and IgM seropositivity among 2456 Lebanese pregnant women was 82.6% and 1.8% respectively. The highest IgG seropositivity is among the age group of 35-44 years (87.81%) and at the governorate of "Mount Lebanon" (82.95%). Sixty-four seroconversions were detected and two abortions due to T. gondii infection during pregnancy were recorded. CONCLUSIONS: The seroprevalence of anti-T. gondii IgG among the screened pregnant women in Lebanon is the highest in the Arab region. These results highlight the importance of running a national sample survey to estimate the real potential burden of this infection and its impact on maternal and fetal health.
Authors: Zafar Rasheed; Ali Shariq; Ghaida B AlQefari; Ghayda S Alwahbi; Amal I Aljuaythin; Fidaa S Alsuhibani; Daliyah F Alotaibi; Shahad S Aljohani; Ruqiah Alghasham; Thamir Alsaeed; Nada A Alharbi; Osamah Al Rugaie; Waleed Al Abdulmonem; Osama F Sharaf Journal: Womens Health (Lond) Date: 2021 Jan-Dec
Authors: Abdulelah H Al-Adhroey; Amat Al-Khaleq O Mehrass; Abdulqawi A Al-Shammakh; Abdullatif D Ali; Mohammed Y M Akabat; Hesham M Al-Mekhlafi Journal: BMC Infect Dis Date: 2019-12-30 Impact factor: 3.090