Nuri Kaydıhan1, Kimia Çepni2, Şefika Arzu Ergen2, Mustafa Şükrü Şenocak3, Didem Çolpan Öksüz2. 1. Department of Radiation Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. nuri.kaydihan@istanbul.edu.tr. 2. Department of Radiation Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. 3. Department of Biostatistics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Abstract
PURPOSE: Our objective was to analyze kidney damage using glomerular filtration rate (GFR) and dynamic renal scintigraphy (DRS) compared with dose volume histogram (DVH) parameters in gastric cancer patients. MATERIALS AND METHODS: Twenty-two gastric cancer patients treated with postoperative chemoradiotherapy were retrospectively evaluated. Student's t test was used to compare pre- and posttreatment GFR and creatinine values. The relative contribution of the left and right kidney in DRS results was expressed as left-to-right ratio (L/R), and the percentage of initial and control participation ratio difference was calculated. Spearman's correlation analysis was used to compare the percentage difference of L/R ratio with DVH parameters of each kidney. RESULTS: In DRS analysis, decrease in left kidney cortical function was observed in one patient. V5-V10 of the left and bilateral kidneys were significantly associated with GFR decline. None of the DVH parameter was significantly associated with L/R ratio. However, the V15 and Dmean of the bilateral kidney were significantly correlated with greater decrease in L/R ratio in seven patients whose posttreatment DRS period was > 12 months. CONCLUSIONS: Decline in renal function, even with current renal constraints, was observed. Minimization of V5, V10, and V15 and mean dose (Dmean) to the kidney should be considered.
PURPOSE: Our objective was to analyze kidney damage using glomerular filtration rate (GFR) and dynamic renal scintigraphy (DRS) compared with dose volume histogram (DVH) parameters in gastric cancerpatients. MATERIALS AND METHODS: Twenty-two gastric cancerpatients treated with postoperative chemoradiotherapy were retrospectively evaluated. Student's t test was used to compare pre- and posttreatment GFR and creatinine values. The relative contribution of the left and right kidney in DRS results was expressed as left-to-right ratio (L/R), and the percentage of initial and control participation ratio difference was calculated. Spearman's correlation analysis was used to compare the percentage difference of L/R ratio with DVH parameters of each kidney. RESULTS: In DRS analysis, decrease in left kidney cortical function was observed in one patient. V5-V10 of the left and bilateral kidneys were significantly associated with GFR decline. None of the DVH parameter was significantly associated with L/R ratio. However, the V15 and Dmean of the bilateral kidney were significantly correlated with greater decrease in L/R ratio in seven patients whose posttreatment DRS period was > 12 months. CONCLUSIONS: Decline in renal function, even with current renal constraints, was observed. Minimization of V5, V10, and V15 and mean dose (Dmean) to the kidney should be considered.
Authors: Laura A Dawson; Brian D Kavanagh; Arnold C Paulino; Shiva K Das; Moyed Miften; X Allen Li; Charlie Pan; Randall K Ten Haken; Timothy E Schultheiss Journal: Int J Radiat Oncol Biol Phys Date: 2010-03-01 Impact factor: 7.038
Authors: A E Dassen; V E P P Lemmens; L V van de Poll-Franse; G J Creemers; S J Brenninkmeijer; D J Lips; A A M Vd Wurff; K Bosscha; J W W Coebergh Journal: Eur J Cancer Date: 2010-03-08 Impact factor: 9.162
Authors: A Yuriko Minn; Annie Hsu; Trang La; Pamela Kunz; George A Fisher; James M Ford; Jeffrey A Norton; Brendan Visser; Karyn A Goodman; Albert C Koong; Daniel T Chang Journal: Cancer Date: 2010-08-15 Impact factor: 6.860