| Literature DB >> 29063763 |
Ryuji Uchida1, Daiki Lee1, Ibuki Suwa1, Masaki Ohtawa1, Nozomu Watanabe1, Ayumu Demachi1, Satoshi Ohte1, Takenobu Katagiri2, Tohru Nagamitsu1, Hiroshi Tomoda1.
Abstract
Three new compounds, designated scopranones A-C, were isolated from the culture broth of a soil isolate, Streptomyces sp. BYK-11038, and shown to be inhibitors of bone morphogenetic protein (BMP) induced alkaline phosphatase activity in a BMP receptor mutant cell line. The structures were elucidated using NMR and other spectral data. The scopranones have an unusual structure with two atypical scooplike moieties linked at the tails to form part of a unique 3-furanone ring.Entities:
Year: 2017 PMID： 29063763 DOI： 10.1021/acs.orglett.7b03003
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005