Literature DB >> 29061755

Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake.

T Mulder1, M F Q Kluytmans-van den Bergh2,3,4, R M P H Crolla5, A A M Ermens6, J Romme4, N E Van't Veer7, J A J W Kluytmans2,4.   

Abstract

Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  antibiotic prophylaxis; surgery; tobramycin

Mesh：

Substances：

Year:  2017        PMID： 29061755      PMCID： PMC5740342          DOI： 10.1128/AAC.01723-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  [Optimizing antibiotics policy in the Netherlands. V. SWAB guidelines for perioperative antibiotic prophylaxis. Foundation Antibiotics Policy Team].

Authors:  M E van Kasteren; I C Gyssens; B J Kullberg; H A Bruining; E E Stobberingh; R J Goris
Journal:  Ned Tijdschr Geneeskd       Date:  2000-10-21

2.  Selective digestive tract decontamination and selective oropharyngeal decontamination and antibiotic resistance in patients in intensive-care units: an open-label, clustered group-randomised, crossover study.

Authors:  Anne Marie G A de Smet; Jan A J W Kluytmans; Hetty E M Blok; Ellen M Mascini; Robin F J Benus; Alexandra T Bernards; Ed J Kuijper; Maurine A Leverstein-van Hall; Arjan R Jansz; Bartelt M de Jongh; Gerard J van Asselt; Ine H M E Frenay; Steven F T Thijsen; Simon N M Conijn; Jan A Kaan; Jan P Arends; Patrick D J Sturm; Martin C J Bootsma; Marc J M Bonten
Journal:  Lancet Infect Dis       Date:  2011-03-21       Impact factor: 25.071

Review 3.  Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project.

Authors:  Dale W Bratzler; Peter M Houck
Journal:  Am J Surg       Date:  2005-04       Impact factor: 2.565

Review 4.  Systematic review of perioperative selective decontamination of the digestive tract in elective gastrointestinal surgery.

Authors:  D Roos; L M Dijksman; J G Tijssen; D J Gouma; M F Gerhards; H M Oudemans-van Straaten
Journal:  Br J Surg       Date:  2013-11       Impact factor: 6.939

Review 5.  Antimicrobial prophylaxis for colorectal surgery.

Authors:  Richard L Nelson; Ed Gladman; Marija Barbateskovic
Journal:  Cochrane Database Syst Rev       Date:  2014-05-09

6.  Simple and sensitive method for quantification of low tobramycin concentrations in human plasma using HPLC-MS/MS.

Authors:  Milly E Attema-de Jonge; Judith M Bekkers; Heleen M Oudemans-van Straaten; Rolf W Sparidans; Eric J F Franssen
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2008-01-04       Impact factor: 3.205

7.  Decontamination of the digestive tract and oropharynx in ICU patients.

Authors:  A M G A de Smet; J A J W Kluytmans; B S Cooper; E M Mascini; R F J Benus; T S van der Werf; J G van der Hoeven; P Pickkers; D Bogaers-Hofman; N J M van der Meer; A T Bernards; E J Kuijper; J C A Joore; M A Leverstein-van Hall; A J G H Bindels; A R Jansz; R M J Wesselink; B M de Jongh; P J W Dennesen; G J van Asselt; L F te Velde; I H M E Frenay; K Kaasjager; F H Bosch; M van Iterson; S F T Thijsen; G H Kluge; W Pauw; J W de Vries; J A Kaan; J P Arends; L P H J Aarts; P D J Sturm; H I J Harinck; A Voss; E V Uijtendaal; H E M Blok; E S Thieme Groen; M E Pouw; C J Kalkman; M J M Bonten
Journal:  N Engl J Med       Date:  2009-01-01       Impact factor: 91.245

8.  Antibiotic levels in bronchial tree and in serum during selective digestive decontamination.

Authors:  H Gastinne; M Wolff; G Lachatre; R Boiteau; F P Savy
Journal:  Intensive Care Med       Date:  1991       Impact factor: 17.440

9.  Acute renal failure due to tobramycin intoxication during selective digestive tract decontamination.

Authors:  D Ramnarain; D W de Lange; J Meulenbelt
Journal:  Intensive Care Med       Date:  2011-05-13       Impact factor: 17.440

10.  Systemic tobramycin concentrations during selective decontamination of the digestive tract in intensive care unit patients on continuous venovenous hemofiltration.

Authors:  Meriel Mol; Hendrikus J M van Kan; Marcus J Schultz; Evert de Jonge
Journal:  Intensive Care Med       Date:  2008-02-19       Impact factor: 17.440
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