Regional localization of mouse Abl and Mos proto-oncogenes by in situ hybridization.

Two proto-oncogenes, Abl and Mos, have been physically localized on their respective mouse chromosomes by in situ hybridization. By means of Robertsonian translocations to facilitate chromosome identification, Abl was regionally assigned to 2B while Mos was assigned to 4A1-A2. Polymorphisms for these genes have not been reported in genomic DNA from standard inbred strains, nor were they found in this study, thereby prohibiting genetic mapping by meiotic recombination. These physical mapping data, however, extend the number of homologous genes assigned to chromosomal regions in both man and mouse, and better define the segments of conservation on mouse chromosome 2/human chromosome 9 and mouse chromosome 4/human chromosome 8, respectively.