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Literature DB >> 2905922

Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus.

P Seubert¹, J Larson, M Oliver, M W Jung, M Baudry, G Lynch.

Abstract

Stimulation of N-methyl-D-aspartate (NMDA) receptors was found to induce proteolysis of brain spectrin in hippocampal slices. The effect was dependent upon extracellular calcium, blocked by the antagonist 2-amino-5-phosphonovalerate (AP5), and was not reproduced by potassium-induced depolarization. These results are consistent with the hypothesis that the involvement of NMDA receptors in plasticity and excitotoxicity is at least partially mediated by calcium-activated proteolysis of cytoskeletal proteins.

Entities: Chemical Gene

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Year: 1988 PMID： 2905922 DOI： 10.1016/0006-8993(88)91222-x

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

19 in total

1. Lamina-specific synaptic activation causes domain-specific alterations in dendritic immunostaining for MAP2 and CAM kinase II.

Authors: O Steward; S Halpain
Journal: J Neurosci Date: 1999-09-15 Impact factor: 6.167

2. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules.

Authors: D W Allison; A S Chervin; V I Gelfand; A M Craig
Journal: J Neurosci Date: 2000-06-15 Impact factor: 6.167

Review 3. Regulation of calpain-2 in neurons: implications for synaptic plasticity.

Authors: Sohila Zadran; Xiaoning Bi; Michel Baudry
Journal: Mol Neurobiol Date: 2010-10-06 Impact factor: 5.590

4. Sequential degradation of alphaII and betaII spectrin by calpain in glutamate or maitotoxin-stimulated cells.

Authors: Susan B Glantz; Carol D Cianci; Rathna Iyer; Deepti Pradhan; Kevin K W Wang; Jon S Morrow
Journal: Biochemistry Date: 2007-01-16 Impact factor: 3.162

5. Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.

Authors: Ming C Liu; Linnet Akinyi; Dancia Scharf; Jixiang Mo; Stephen F Larner; Uwe Muller; Monika W Oli; Wenrong Zheng; Firas Kobeissy; Linda Papa; Xi-Chun Lu; Jitendra R Dave; Frank C Tortella; Ronald L Hayes; Kevin K W Wang
Journal: Eur J Neurosci Date: 2010-02 Impact factor: 3.386

Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus.

1. Lamina-specific synaptic activation causes domain-specific alterations in dendritic immunostaining for MAP2 and CAM kinase II.

2. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules.

Review 3. Regulation of calpain-2 in neurons: implications for synaptic plasticity.

4. Sequential degradation of alphaII and betaII spectrin by calpain in glutamate or maitotoxin-stimulated cells.

5. Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.

6. Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons.

7. Calcium-mediated modulation of N-methyl-D-aspartate (NMDA) responses in cultured rat hippocampal neurones.

8. Spectrin Breakdown Products (SBDPs) as Potential Biomarkers for Neurodegenerative Diseases.

9. Proteolysis of filament proteins in glial and neuronal cells after in vivo stimulation of hippocampal NMDA receptors.

Review 10. The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states.