Carlo Giovanni Carrera1, Paolo Dapavo2, Piergiorgio Malagoli3, Luigi Naldi4, Luisa Arancio1, Francesca Gaiani3, Colin Gerard Egan5, Marco Di Mercurio6, Angelo Cattaneo1. 1. a U.O. Dermatologia , Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico , Milan , Italy. 2. b Department of Medical Sciences, Section of Dermatology , University of Turin , Turin , Italy. 3. c Dermatology Unit , Azienda Ospedaliera San Donato Milanese , Milan , Italy. 4. d U.O.C. Dermatologia , Ospedale San Bortolo - Azienda ULSS8 , Berica (VI) , Italy. 5. e CE Medical Writing , Pisa , Italy. 6. f Division of Dermatology , Humanitas Research Hospital , Milan , Italy.
Abstract
BACKGROUND: Few studies have compared the use of different biologics in a real-life setting in plaque psoriasis patients. OBJECTIVE: To compare the efficacy of biologics in psoriasis/psoriatic arthritis patients. METHODS: Patients treated with adalimumab, etanercept and ustekinumab for at least 16 weeks were included. Achievement of Psoriasis Area Severity Index (PASI), PASI 90/100 response and time taken to achieve PASI 90/100 response were measured. Logistic regression was used to evaluate the effect of psoriasis localization on achievement of PASI 100 response. RESULTS: Two hundred and fifty five patients were included. No difference was observed in PASI 90 response between etanercept and ustekinumab (65.5 vs. 55.4%), while adalimumab-treated patients had a higher response versusustekinumab (71.6 vs. 55.4%, p = .02). More patients achieved complete remission (PASI 100 response) with adalimumab versus etanercept (65.7 vs. 23%, p < .001) or ustekinumab (65.7 vs. 44.6%, p = .003). Adalimumab-treated patients achieving PASI 90 responded more quickly (by three and six months) versus ustekinumab or etanercept. PASI100 response was achieved in ∼43% of adalimumab and ustekinumab treated-patients by three months versus etanercept (14.3%), increasing to 92.5, 85.4 and 35.7%, respectively by six months. PASI100 response was associated with psoriasis nail involvement or genital psoriasis. CONCLUSION: In the real-life setting, adalimumab was the most effective biological agent for the treatment of plaque psoriasis.
BACKGROUND: Few studies have compared the use of different biologics in a real-life setting in plaque psoriasispatients. OBJECTIVE: To compare the efficacy of biologics in psoriasis/psoriatic arthritispatients. METHODS:Patients treated with adalimumab, etanercept and ustekinumab for at least 16 weeks were included. Achievement of Psoriasis Area Severity Index (PASI), PASI 90/100 response and time taken to achieve PASI 90/100 response were measured. Logistic regression was used to evaluate the effect of psoriasis localization on achievement of PASI 100 response. RESULTS: Two hundred and fifty five patients were included. No difference was observed in PASI 90 response between etanercept and ustekinumab (65.5 vs. 55.4%), while adalimumab-treated patients had a higher response versusustekinumab (71.6 vs. 55.4%, p = .02). More patients achieved complete remission (PASI 100 response) with adalimumab versus etanercept (65.7 vs. 23%, p < .001) or ustekinumab (65.7 vs. 44.6%, p = .003). Adalimumab-treated patients achieving PASI 90 responded more quickly (by three and six months) versus ustekinumab or etanercept. PASI100 response was achieved in ∼43% of adalimumab and ustekinumab treated-patients by three months versus etanercept (14.3%), increasing to 92.5, 85.4 and 35.7%, respectively by six months. PASI100 response was associated with psoriasis nail involvement or genital psoriasis. CONCLUSION: In the real-life setting, adalimumab was the most effective biological agent for the treatment of plaque psoriasis.
Authors: Marloes E Van Muijen; Sarah E Thomas; Hans M M Groenewoud; Marisol E Otero; Paul M Ossenkoppele; Marcellus D Njoo; Sharon R P Dodemont; Else N Kop; Maartje A M Berends; Marjolein I A Koetsier; Johannes M Mommers; John E M Körver; Ron A Tupker; Marjolein S De Bruin-Weller; Lizelotte J M T Weppner-Parren; Bas Peters; Marloes M Kleinpenning; Astrid L A Kuijpers; W Peter Arnold; Paula P M Van Lümig; Juul M P A Van den Reek; Elke M G J De Jong Journal: Acta Derm Venereol Date: 2022-05-16 Impact factor: 3.875
Authors: J Seneschal; J-P Lacour; A Bewley; M Faurby; C Paul; G Pellacani; C De Simone; L Horne; A Sohrt; M Augustin; E Hammond; K Reich Journal: J Eur Acad Dermatol Venereol Date: 2020-06-08 Impact factor: 6.166