Vasiliki Spyropoulou1, Gabriel Brändle2, Albane Bertha Rosa Maggio3, Rebecca Anderson Della Llana4, Abdessalam Cherkaoui5, Gesuele Renzi5, Jacques Schrenzel5,6, Sergio Manzano7, Dimitri Ceroni8. 1. Child and Adolescent Department, University Hospitals of Geneva, Str Willy-Donzé 6, CH-1211, Geneva 14, Switzerland. vasiliki.spyropoulou@hcuge.ch. 2. Child and Adolescent Department, University Hospitals of Geneva, Str Willy-Donzé 6, CH-1211, Geneva 14, Switzerland. 3. Pediatric Sport Medicine and Obesity Care Program, University Hospitals of Geneva, Geneva, Switzerland. 4. Intensive Care Unit, University Hospitals of Geneva, Geneva, Switzerland. 5. Clinical Microbiology Laboratory, Service of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland. 6. Genomic Research Laboratory, Service of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland. 7. Pediatric Emergency Division, University Hospitals of Geneva, Geneva, Switzerland. 8. Pediatric Orthopedic Service, University Hospitals of Geneva, Geneva, Switzerland.
Abstract
BACKGROUND: The aim of this pilot study was to investigate the extent of oropharyngeal Kingella kingae carriage during the first 6 months of life. METHODS: We conducted a monocentric transversal pilot study on healthy children younger than 6 months in order to define the oropharyngeal carriage rate. Participants were recruited between December 2013 and September 2015 among children without symptoms or signs of invasive infections. RESULTS: We demonstrated an oropharyngeal carriage rate of 0.67% in children younger than 6 months. Due to the really low carriage rate, it was not possible to draw statistically significant conclusion about any other characteristic of our population. CONCLUSIONS: The present study suggests that the oropharyngeal carriage of Kingella kingae among a Swiss population of healthy infants younger than 6 months is exceptional. The scarcity of colonization and disease in the early months of life suggests thus that defense against mucosal carriage and invasive infection is above all provided by vertically acquired immunity. Limited exposure of the neonates due to limited social contacts may also represent another factor avoiding neonates' mucosal Kingella kingae carriage.
BACKGROUND: The aim of this pilot study was to investigate the extent of oropharyngeal Kingella kingae carriage during the first 6 months of life. METHODS: We conducted a monocentric transversal pilot study on healthy children younger than 6 months in order to define the oropharyngeal carriage rate. Participants were recruited between December 2013 and September 2015 among children without symptoms or signs of invasive infections. RESULTS: We demonstrated an oropharyngeal carriage rate of 0.67% in children younger than 6 months. Due to the really low carriage rate, it was not possible to draw statistically significant conclusion about any other characteristic of our population. CONCLUSIONS: The present study suggests that the oropharyngeal carriage of Kingella kingae among a Swiss population of healthy infants younger than 6 months is exceptional. The scarcity of colonization and disease in the early months of life suggests thus that defense against mucosal carriage and invasive infection is above all provided by vertically acquired immunity. Limited exposure of the neonates due to limited social contacts may also represent another factor avoiding neonates' mucosal Kingella kingae carriage.
Entities:
Keywords:
Kingella kingae; oropharyngeal carriage; young infants
Authors: T Riordan; K Cartwright; N Andrews; J Stuart; A Burris; A Fox; R Borrow; T Douglas-Riley; J Gabb; A Miller Journal: Epidemiol Infect Date: 1998-12 Impact factor: 2.451
Authors: G Aniansson; B Alm; B Andersson; P Larsson; O Nylén; H Peterson; P Rignér; M Svanborg; C Svanborg Journal: J Infect Dis Date: 1992-06 Impact factor: 5.226