Enrico Collantoni1,2, Marco Solmi1,2, Davide Gallicchio1,2, Paolo Santonastaso1,2,3, Paolo Meneguzzo1,2, Andrè F Carvalho4, Brendon Stubbs5,6,7, Maurizio Clementi8, Claudia Pinato8, Monica Forzan8, Matteo Cassina8, Francesca Fontana2, Ivana Piva2, Roberta Siani2, Pierandrea Salvo2, Elena Tenconi1,2,3, Nicola Veronese9, Christoph U Correll10,11, Angela Favaro1,2,3. 1. Neuroscience Department, University of Padua, Italy. 2. BIO.VEDA Group (Biobanca Veneta per i Disturbi dell'Alimentazione: Biobank of the Veneto Region Eating Disorders Units), Italy. 3. Centro Neuroscienze Cognitive (CNC), University of Padua, Italy. 4. Translational Psychiatry Research Group, Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Brazil. 5. Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. 6. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, UK. 7. Faculty of Health, Social Care and Education, Anglia Ruskin University, UK. 8. Clinical Genetics Unit, Department of Woman and Child Health, University of Padua, Italy. 9. National Research Council, Ageing Section, Italy. 10. Department of Psychiatry Research, Northwell Health, The Zucker Hillside Hospital, Glen Oaks, NY, USA. 11. Department of Psychiatry and Molecular Medicine Hempstead, Hofstra Northwell School of Medicine, Hempstead, NY, USA.
Abstract
OBJECTIVES: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). METHODS: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian 'Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. RESULTS: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I2 = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I2 = 0-44%). CONCLUSIONS: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs.
OBJECTIVES: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). METHODS: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian 'Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. RESULTS: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I2 = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I2 = 0-44%). CONCLUSIONS: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs.
Authors: Marco Solmi; Joaquim Radua; Brendon Stubbs; Valdo Ricca; Davide Moretti; Daniele Busatta; Andre F Carvalho; Elena Dragioti; Angela Favaro; Alessio Maria Monteleone; Jae Il Shin; Paolo Fusar-Poli; Giovanni Castellini Journal: Braz J Psychiatry Date: 2020-09-28 Impact factor: 2.697