Amirhossein Bahreyni1, Majid Khazaei2, Majid Rajabian3, Mikhail Ryzhikov4, Amir Avan5,6, Seyed M Hassanian5,7,8. 1. Faculty of Medicine, Department of Clinical Biochemistry and Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran. 2. Faculty of Medicine, Department of Medical Physiology, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Department of Biochemistry, Payam-e-Noor University, Mashhad, Iran. 4. Division of Pulmonary and Critical Care Medicine, Washington University, School of Medicine, Saint Louis, MO, USA. 5. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 6. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 7. Faculty of Medicine, Department of Medical Biochemistry, Mashhad University of Medical Sciences, Mashhad, Iran. 8. Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract
OBJECTIVES: Adenosine concentration significantly increases in tumour microenvironment contributing to tumorigenic processes including cell proliferation, survival, invasion and of special interest in this review angiogenesis. KEY FINDINGS: This review summarizes the role of pharmacological adenosine receptor agonist and antagonist in regulating angiogenesis for a better understanding and hence a better management of angiogenesis-associated disorders. SUMMARY: Depending upon the pharmacological characteristics of adenosine receptor subtypes, adenosine elicits anti- or pro-angiogenic responses in stimulated cells. Inhibition of the stimulatory effect of adenosine signalling on angiogenesis using specific pharmacological adenosine receptor agonist, and antagonist is a potentially novel strategy to suppress angiogenesis in tumours.
OBJECTIVES:Adenosine concentration significantly increases in tumour microenvironment contributing to tumorigenic processes including cell proliferation, survival, invasion and of special interest in this review angiogenesis. KEY FINDINGS: This review summarizes the role of pharmacological adenosine receptor agonist and antagonist in regulating angiogenesis for a better understanding and hence a better management of angiogenesis-associated disorders. SUMMARY: Depending upon the pharmacological characteristics of adenosine receptor subtypes, adenosine elicits anti- or pro-angiogenic responses in stimulated cells. Inhibition of the stimulatory effect of adenosine signalling on angiogenesis using specific pharmacological adenosine receptor agonist, and antagonist is a potentially novel strategy to suppress angiogenesis in tumours.
Authors: Ming Chen; Yi Li; Xiang Huang; Ya Gu; Shang Li; Pengbin Yin; Licheng Zhang; Peifu Tang Journal: Bone Res Date: 2021-03-22 Impact factor: 13.567