Ewa Sapiejka1, Patrycja Krzyżanowska2, Dariusz Walkowiak3, Ewa Wenska-Chyży2, Mariusz Szczepanik2, Szczepan Cofta4, Andrzej Pogorzelski5, Wojciech Skorupa6, Jarosław Walkowiak2. 1. The Specialist Centre for Medical Care of Mother and Child, Gdańsk-Oliwa, Poland. 2. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland. 3. Department of Organization and Management in Health Care, Poznan University of Medical Sciences, Poland. 4. University Hospital of Lord?s Transfiguration, Partner of Poznan University of Medical Sciences, Poland. 5. Department of Pulmonology and Cystic Fibrosis, Institute of Tuberculosis and Lung Diseases, Rabka-Zdrój, Poland. 6. I Department of Lung Diseases, National Institute for Tuberculosis and Lung Diseases, Warsaw, Poland.
Abstract
BACKGROUND: Routine administration of vitamin A, recommended in CF patients, can help to prevent its deficiency. However, high vitamin A supplementation may lead to its excessive level and possible toxicity. Therefore, the aim of the present study was to assess the status of vitamin A and the determinants of its body resources in CF patients. METHODS: In 196 CF patients aged from 4 months to 47 years, the following parameters were analysed: nutritional status (standardized body weight and height, serum albumin concentration) and clinical expression of disease (lung function - spirometry; biochemical markers of liver function - ALT, AST, GGT; respiratory tract colonization by Pseudomonas aeruginosa; diabetes; cirrhosis, non-cirrhotic liver disease; exocrine pancreatic function - fecal elastase-1 concentration; blood clotting - INR and vitamin A supplementation). RESULTS: Median vitamin A concentration in the study group was 383.0 ng/ml (1st-3rd quartile: 316.5-457.0). Vitamin A deficiency was found in 32 (16.3%) subjects studied. Vitamin A concentrations above the reference range were observed only in 3 (1.5%) CF patients. CF patients with vitamin A deficiency were significantly older and had lower values of FEV1 compared to CF subjects with normal vitamin A status. Moreover, vitamin A deficiency occurred more frequently in CF patients with diabetes, Pseudomonas aeruginosa colo- nization, worse lung function and in those without vitamin A supplementation. However, in multiple linear regression analyses, none of the independent variables was documented to be important for predicting vita- min A status. CONCLUSIONS: Vitamin A body resources in CF patients are mostly normal. Moreover, there are no good de- terminants of vitamin A status in these patients. Further studies targeted at exploring potential toxicity and deficiencies of vitamin A in CF patients are needed.
BACKGROUND: Routine administration of vitamin A, recommended in CFpatients, can help to prevent its deficiency. However, high vitamin A supplementation may lead to its excessive level and possible toxicity. Therefore, the aim of the present study was to assess the status of vitamin A and the determinants of its body resources in CFpatients. METHODS: In 196 CFpatients aged from 4 months to 47 years, the following parameters were analysed: nutritional status (standardized body weight and height, serum albumin concentration) and clinical expression of disease (lung function - spirometry; biochemical markers of liver function - ALT, AST, GGT; respiratory tract colonization by Pseudomonas aeruginosa; diabetes; cirrhosis, non-cirrhotic liver disease; exocrine pancreatic function - fecal elastase-1 concentration; blood clotting - INR and vitamin A supplementation). RESULTS: Median vitamin A concentration in the study group was 383.0 ng/ml (1st-3rd quartile: 316.5-457.0). Vitamin A deficiency was found in 32 (16.3%) subjects studied. Vitamin A concentrations above the reference range were observed only in 3 (1.5%) CFpatients. CFpatients with vitamin A deficiency were significantly older and had lower values of FEV1 compared to CF subjects with normal vitamin A status. Moreover, vitamin A deficiency occurred more frequently in CFpatients with diabetes, Pseudomonas aeruginosacolo- nization, worse lung function and in those without vitamin A supplementation. However, in multiple linear regression analyses, none of the independent variables was documented to be important for predicting vita- min A status. CONCLUSIONS:Vitamin A body resources in CFpatients are mostly normal. Moreover, there are no good de- terminants of vitamin A status in these patients. Further studies targeted at exploring potential toxicity and deficiencies of vitamin A in CFpatients are needed.
Authors: Jan K Nowak; Paulina Sobkowiak; Sławomira Drzymała-Czyż; Patrycja Krzyżanowska-Jankowska; Ewa Sapiejka; Wojciech Skorupa; Andrzej Pogorzelski; Agata Nowicka; Irena Wojsyk-Banaszak; Szymon Kurek; Barbara Zielińska-Psuja; Aleksandra Lisowska; Jarosław Walkowiak Journal: Nutrients Date: 2021-12-20 Impact factor: 5.717
Authors: Jan Krzysztof Nowak; Patrycja Krzyżanowska-Jankowska; Sławomira Drzymała-Czyż; Joanna Goździk-Spychalska; Irena Wojsyk-Banaszak; Wojciech Skorupa; Ewa Sapiejka; Anna Miśkiewicz-Chotnicka; Jan Brylak; Barbara Zielińska-Psuja; Aleksandra Lisowska; Jarosław Walkowiak Journal: J Clin Med Date: 2022-01-17 Impact factor: 4.241