Sarah Collinge1, Garreth Prendergast2, Steven T Mayers3, David Marshall4, Poppy Siddell5, Elizabeth Neilly6, Colin D Ferrie7, Gayatri Vadlamani8, Jeremy Macmullen-Price9, Daniel J Warren10, Arshad Zaman11, Paul Chumas12, John Goodden13, Matthew C H J Morrall14. 1. Birch Hill Hospital, Birch Road, Rochdale, OL12 9QB, UK. Electronic address: sarahcollinge@nhs.net. 2. Institute of Psychological Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK. Electronic address: garreth.prendergast@manchester.ac.uk. 3. Complex Rehabilitation Unit, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK. Electronic address: steven.thomas.mayers@gmail.com. 4. Department of Clinical Psychology, South West Yorkshire Partnership NHS Foundation Trust, Newton Lodge, Fieldhead Hospital, Ouchthorpe Lane, WF1 3SP, UK. Electronic address: david.marshall@swyt.nhs.uk. 5. Paediatric Neuropsychology, The Leeds Teaching Hospitals NHS Trust, E Floor, Martin Wing, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. Electronic address: poppysiddell@nhs.net. 6. Health Faculty Team Librarian, Health Sciences Library, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: e.m.neilly@leeds.ac.uk. 7. Oxford Science Editing Limited, John Eccles House, Oxford Science Park, Oxford, OX4 4GP, UK. Electronic address: colindferrie@aol.com. 8. Paediatric Neurology, The Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. Electronic address: gayatri.vadlamani@nhs.net. 9. MRI, The Leeds Teaching Hospitals NHS Trust, G Floor, Jubilee Wing, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. Electronic address: jeremy.macmullen-price1@nhs.net. 10. MRI, The Leeds Teaching Hospitals NHS Trust, G Floor, Jubilee Wing, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. Electronic address: danielwarren@nhs.net. 11. MRI, The Leeds Teaching Hospitals NHS Trust, G Floor, Jubilee Wing, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. Electronic address: a.zaman@leeds.ac.uk. 12. Department of Neurosurgery, The Leeds Teaching Hospitals NHS Trust, G Floor, Jubilee Wing,Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. Electronic address: p.chumas@nhs.net. 13. Department of Neurosurgery, The Leeds Teaching Hospitals NHS Trust, G Floor, Jubilee Wing,Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. Electronic address: j.goodden@nhs.net. 14. Paediatric Neuropsychology, The Leeds Teaching Hospitals NHS Trust, E Floor, Martin Wing, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. Electronic address: m.morrall@nhs.net.
Abstract
PURPOSE: A review of all published evidence for mapping eloquent (motor, language and memory) cortex using advanced functional neuroimaging (functional magnetic resonance imaging [fMRI] and magnetoencephalography [MEG]) for paediatric epilepsy surgery candidates has not been conducted previously. Research in this area has predominantly been in adult populations and applicability of these techniques to paediatric populations is less established. METHODS: A review was performed using an advanced systematic search and retrieval of all published papers examining the use of functional neuroimaging for paediatric epilepsy surgery candidates. RESULTS: Of the 2724 papers retrieved, 34 met the inclusion criteria. Total paediatric participants identified were 353 with an age range of 5 months-19 years. Sample sizes and comparisons with alternative investigations to validate techniques are small and variable paradigms are used. Sensitivity 0.72 (95% CI 0.52-0.86) and specificity 0.60 (95% CI 0.35-0.92) values with a Positive Predictive Value of 74% (95% CI 61-87) and a Negative Predictive Value of 65% (95% CI 52-78) for fMRI language lateralisation with validation, were obtained. Retrieved studies indicate evidence that both fMRI and MEG are able to provide information lateralising and localising motor and language functions. CONCLUSIONS: A striking finding of the review is the paucity of studies (n=34) focusing on the paediatric epilepsy surgery population. For children, it remains unclear which language and memory paradigms produce optimal activation and how these should be quantified in a statistically robust manner. Consensus needs to be achieved for statistical analyses and the uniformity and yield of language, motor and memory paradigms. Larger scale studies are required to produce patient series data which clinicians may refer to interpret results objectively. If functional imaging techniques are to be the viable alternative for pre-surgical mapping of eloquent cortex for children, paradigms and analyses demonstrating concordance with independent measures must be developed.
PURPOSE: A review of all published evidence for mapping eloquent (motor, language and memory) cortex using advanced functional neuroimaging (functional magnetic resonance imaging [fMRI] and magnetoencephalography [MEG]) for paediatric epilepsy surgery candidates has not been conducted previously. Research in this area has predominantly been in adult populations and applicability of these techniques to paediatric populations is less established. METHODS: A review was performed using an advanced systematic search and retrieval of all published papers examining the use of functional neuroimaging for paediatric epilepsy surgery candidates. RESULTS: Of the 2724 papers retrieved, 34 met the inclusion criteria. Total paediatric participants identified were 353 with an age range of 5 months-19 years. Sample sizes and comparisons with alternative investigations to validate techniques are small and variable paradigms are used. Sensitivity 0.72 (95% CI 0.52-0.86) and specificity 0.60 (95% CI 0.35-0.92) values with a Positive Predictive Value of 74% (95% CI 61-87) and a Negative Predictive Value of 65% (95% CI 52-78) for fMRI language lateralisation with validation, were obtained. Retrieved studies indicate evidence that both fMRI and MEG are able to provide information lateralising and localising motor and language functions. CONCLUSIONS: A striking finding of the review is the paucity of studies (n=34) focusing on the paediatric epilepsy surgery population. For children, it remains unclear which language and memory paradigms produce optimal activation and how these should be quantified in a statistically robust manner. Consensus needs to be achieved for statistical analyses and the uniformity and yield of language, motor and memory paradigms. Larger scale studies are required to produce patient series data which clinicians may refer to interpret results objectively. If functional imaging techniques are to be the viable alternative for pre-surgical mapping of eloquent cortex for children, paradigms and analyses demonstrating concordance with independent measures must be developed.
Authors: Syed Ali Ahsan; Kassem Chendeb; Robert G Briggs; Luke R Fletcher; Ryan G Jones; Arpan R Chakraborty; Cameron E Nix; Christina C Jacobs; Alison M Lack; Daniel T Griffin; Charles Teo; Michael Edward Sughrue Journal: J Neurooncol Date: 2020-01-01 Impact factor: 4.130
Authors: Steven Beumer; Paul Boon; Debby C W Klooster; Raymond van Ee; Evelien Carrette; Maarten M Paulides; Rob M C Mestrom Journal: Brain Sci Date: 2022-05-07