| Literature DB >> 29055795 |
Yanjiao Li1, Wenwen Guo2, Xiaodan Su3, Lin Ou-Yang4, Meng Dang3, Jun Tao3, Guangming Lu5, Zhaogang Teng6.
Abstract
In the work, small size thioether-bridged mesoporous organosilica nanorod (MONRs) are successfully synthesized using cetyltrimethylammonium bromide (CTAB) as structure-directing agent and bis[3-(triethoxysilyl)propyl]tetrasulfide (TETS) and tetraethoxysilane (TEOS) as co-precursors. The MONRs have tunable aspect ratios of 2, 3, and 4 (denoted as MONRs-2, MONRs-3, and MONRs-4), small and controllable lengths (75-310nm), high surface area (570-870cm2g-1), uniform mesopores (2.4-2.6nm), large pore volume (0.34cm3g-1), and excellent biocompatibility. The uptake of the MONRs by multidrug resistant human breast cancer MDR-MCF-7 cells is related to their aspect ratios. The MONRs-3 shows a faster and higher cellular internalization compared to the MONRs-4 and MONRs-2, respectively. Thanks to the high cellular uptake, doxorubicin (DOX) loaded MONRs-3 show obviously improved chemotherapeutic effect on MDR-MCF-7 cancer cells. It is expected that the MONRs provide a useful platform for drug delivery and therapeutics.Entities:
Keywords: Cellular uptake; Drug delivery; Mesoporous organosilica; Nanorods; Small size
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Year: 2017 PMID： 29055795 DOI： 10.1016/j.jcis.2017.10.006
Source DB: PubMed Journal: J Colloid Interface Sci ISSN： 0021-9797 Impact factor: 8.128