Jesús M Gómez-Martin1, José A Balsa2, Enrique Aracil3, María Insenser4, Pablo Priego5, Héctor F Escobar-Morreale4, José I Botella-Carretero6. 1. Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain. 2. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain; Department of Endocrinology and Nutrition, Hospital Infanta Sofía & Universidad Europea, Madrid, Spain. 3. Department of Vascular Surgery, Hospital Universitario Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain. 4. Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain; Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain. 5. Department of General and Gastrointestinal Surgery, Hospital Universitario Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain. 6. Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain. Electronic address: joseignacio.botella@salud.madrid.org.
Abstract
BACKGROUND & AIMS: Obesity surgery induces beneficial effects in metabolic and cardiovascular parameters. Adiponectin increase might be associated with some of these changes. However, direct comparison between different surgical techniques has not been extensively performed. METHODS: We studied 20 obese women submitted to laparoscopic Roux en Y gastric bypass (RYGB) and 20 to sleeve gastrectomy (SG). Twenty control women matched for age and baseline metabolic profiles were also included. Both patients and controls were followed up for one year after surgery or conventional treatment with diet and exercise, respectively. Serum adiponectin was measured at baseline, 6 months and 1 year after, as well as lipid profiles, sex hormone binding globulin (SHBG), fasting glucose and insulin. Carotid intima-media thickness was measured by ultrasonography at baseline and after 1 year. RESULTS: Circulating adiponectin increased after obesity surgery (more markedly following RYGB than after SG), whereas no changes were observed in the controls (Wilks' λ = 0.659, P < 0.001 for the interaction, P < 0.001 for RYGB vs. controls, P = 0.016 for SG vs. controls, P = 0.040 for RYGB vs. SG). The percentage increment in adiponectin correlated positively with changes in SHBG (r = 0.404, P = 0.002) and negatively with changes in weight (r = -0.531, P < 0.001), waist circumference (r = -0.426, P = 0.001), fasting glucose (r = -0.356, P = 0.006), and insulin (r = -0.496, P < 0.001). No correlation was found with carotid intima-media thickness (r = -0.055, P = 0.679). CONCLUSIONS: RYGB induces a higher increase in adiponectin than SG, which parallels SHBG, the reduction of fasting insulin and insulin resistance. On the other hand, no association was found with carotid intima-media, lipid profiles or blood pressure.
BACKGROUND & AIMS:Obesity surgery induces beneficial effects in metabolic and cardiovascular parameters. Adiponectin increase might be associated with some of these changes. However, direct comparison between different surgical techniques has not been extensively performed. METHODS: We studied 20 obesewomen submitted to laparoscopic Roux en Y gastric bypass (RYGB) and 20 to sleeve gastrectomy (SG). Twenty control women matched for age and baseline metabolic profiles were also included. Both patients and controls were followed up for one year after surgery or conventional treatment with diet and exercise, respectively. Serum adiponectin was measured at baseline, 6 months and 1 year after, as well as lipid profiles, sex hormone binding globulin (SHBG), fasting glucose and insulin. Carotid intima-media thickness was measured by ultrasonography at baseline and after 1 year. RESULTS: Circulating adiponectin increased after obesity surgery (more markedly following RYGB than after SG), whereas no changes were observed in the controls (Wilks' λ = 0.659, P < 0.001 for the interaction, P < 0.001 for RYGB vs. controls, P = 0.016 for SG vs. controls, P = 0.040 for RYGB vs. SG). The percentage increment in adiponectin correlated positively with changes in SHBG (r = 0.404, P = 0.002) and negatively with changes in weight (r = -0.531, P < 0.001), waist circumference (r = -0.426, P = 0.001), fasting glucose (r = -0.356, P = 0.006), and insulin (r = -0.496, P < 0.001). No correlation was found with carotid intima-media thickness (r = -0.055, P = 0.679). CONCLUSIONS: RYGB induces a higher increase in adiponectin than SG, which parallels SHBG, the reduction of fasting insulin and insulin resistance. On the other hand, no association was found with carotid intima-media, lipid profiles or blood pressure.
Authors: Jesús M Gómez-Martin; Enrique Aracil; María Insenser; Gema de la Peña; Miguel A Lasunción; Julio Galindo; Héctor F Escobar-Morreale; José A Balsa; José I Botella-Carretero Journal: Obes Facts Date: 2020-05-08 Impact factor: 3.942
Authors: Tammy Lo; Renuka S Haridas; Eleanor J M Rudge; Robert P Chase; Keyvan Heshmati; Elizabeth M Lucey; Alison M Weigl; Otatade J Iyoha-Bello; Chelsea O Ituah; Emily J Benjamin; Seth W McNutt; Leena Sathe; Leanna Farnam; Benjamin A Raby; Ali Tavakkoli; Damien C Croteau-Chonka; Eric G Sheu Journal: J Clin Endocrinol Metab Date: 2022-01-18 Impact factor: 6.134
Authors: J M Gómez-Martin; J A Balsa; E Aracil; M Cuadrado-Ayuso; M Rosillo; G De la Peña; M A Lasunción; H F Escobar-Morreale; J I Botella-Carretero Journal: Lipids Health Dis Date: 2018-06-20 Impact factor: 3.876
Authors: Noyan Gokce; Shakun Karki; Alyssa Dobyns; Elaina Zizza; Emily Sroczynski; Joseph N Palmisano; Celestina Mazzotta; Naomi M Hamburg; Luise I Pernar; Brian Carmine; Cullen O Carter; Michael LaValley; Donald T Hess; Caroline M Apovian; Melissa G Farb Journal: JAMA Netw Open Date: 2021-07-01