Shlomit Yust Katz1, David Cachia2, Carlos Kamiya-Matsuoka3, Adriana Olar4, Brett Theeler5, Marta Penas Prado3, Mark R Gilbert6, Terri Armstrong6. 1. Davidoff Cancer Center at Rabin Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel. Electronic address: shlomit2@clalit.org.il. 2. Department of Neuro-oncology, Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, United States. 3. Department of Neuro-Oncology, MD Anderson Cancer Center, United States. 4. Department of Pathology and Neurosurgery, Medical University of South Carolina, Charleston, SC, United States. 5. Department of Neurology and John P. Murtha Cancer Center, Walter Reed National Military Medical Center, United States. 6. Neuro-Oncology Branch, National Institutes of Health, United States.
Abstract
BACKGROUND: Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports. METHODS: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period. RESULTS: Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy. CONCLUSION: Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.
BACKGROUND: Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports. METHODS: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period. RESULTS: Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy. CONCLUSION: Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.
Authors: Brian V Lien; Nolan J Brown; Alexander S Himstead; Benjamin Z Ball; Aileen Guillen; Nischal Acharya; Chen Yi Yang; Ronald Sahyouni; Mari Perez-Rosendahl; Russell N Stitzlein; Frank P K Hsu Journal: Surg Neurol Int Date: 2021-03-30