Chelsea Doktorchik1, Shahirose Premji2, Donna Slater3, Tyler Williamson4, Suzanne Tough5, Scott Patten6. 1. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, TRW Building 3rd Floor, 3280 Hospital Drive NW, Calgary, AB, Canada T2N 4Z6. Electronic address: ctadokto@ucalgary.ca. 2. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, TRW Building 3rd Floor, 3280 Hospital Drive NW, Calgary, AB, Canada T2N 4Z6; Faculty of Nursing, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Room 293 Heritage Medical Research Building, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1. Electronic address: premjis@ucalgary.ca. 3. Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Room 293 Heritage Medical Research Building, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1; Departments of Physiology & Pharmacology and Obstetrics & Gynecology, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1. Electronic address: dmslater@ucalgary.ca. 4. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, TRW Building 3rd Floor, 3280 Hospital Drive NW, Calgary, AB, Canada T2N 4Z6; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Room 293 Heritage Medical Research Building, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1; O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, 3rd Floor TRW Building, 3280 Hospital Drive NW, Calgary, AB, Canada T2N 4Z6. Electronic address: tyler.williamson@ucalgary.ca. 5. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, TRW Building 3rd Floor, 3280 Hospital Drive NW, Calgary, AB, Canada T2N 4Z6; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Room 293 Heritage Medical Research Building, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1; Department of Pediatrics, Cumming School of Medicine, University of Calgary, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8. Electronic address: stough@ucalgary.ca. 6. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, TRW Building 3rd Floor, 3280 Hospital Drive NW, Calgary, AB, Canada T2N 4Z6; O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, 3rd Floor TRW Building, 3280 Hospital Drive NW, Calgary, AB, Canada T2N 4Z6; Department of Psychiatry, Cumming School of Medicine, University of Calgary, 1403 29th Street NW, Calgary, AB, Canada T2N 2T9. Electronic address: patten@ucalgary.ca.
Abstract
BACKGROUND: To determine whether changes in anxiety and depression during pregnancy influence the risk of having a preterm birth (PTB), and whether chronic stress modifies this relationship. METHODS: The data source for the current study is the All Our Babies prospective cohort (AOB). Anxiety and depression were measured at 17-24 weeks and again at 32-36 weeks' gestation using the Spielberg State Anxiety Scale and the Edinburgh Postnatal Depression Scale, respectively. Chronic stress was assessed at 17-24 weeks' gestation as a potential covariate, and was measured using the Perceived Stress Scale. Multivariable logistic regression modeling was used to assess each relationship RESULTS: Women who experienced an increase in anxiety scores, (time point 32-36 weeks, compared to the earlier time point 17-24 weeks), had 2.70 times higher odds of preterm delivery, compared to those with a reduction in anxiety scores (95% CI 1.28, 5.69). Consistent low or high depression scores did not significantly influence the odds of PTB compared to a decrease in depression scores. A co-occurring increase in anxiety and depression scores was not found to increase the risk of PTB, and chronic stress did not modify any of these relationships. LIMITATIONS: This study was limited by a relatively small sample of women who delivered preterm, and therefore it was not possible to conduct additional analyses. Further, the analyses were limited to mostly late preterm infants (32-36 weeks' gestation). CONCLUSIONS: These findings should be validated with additional cohorts and a larger sample size. Ultimately, primary prevention could address anxiety during pregnancy.
BACKGROUND: To determine whether changes in anxiety and depression during pregnancy influence the risk of having a preterm birth (PTB), and whether chronic stress modifies this relationship. METHODS: The data source for the current study is the All Our Babies prospective cohort (AOB). Anxiety and depression were measured at 17-24 weeks and again at 32-36 weeks' gestation using the Spielberg State Anxiety Scale and the Edinburgh Postnatal Depression Scale, respectively. Chronic stress was assessed at 17-24 weeks' gestation as a potential covariate, and was measured using the Perceived Stress Scale. Multivariable logistic regression modeling was used to assess each relationship RESULTS:Women who experienced an increase in anxiety scores, (time point 32-36 weeks, compared to the earlier time point 17-24 weeks), had 2.70 times higher odds of preterm delivery, compared to those with a reduction in anxiety scores (95% CI 1.28, 5.69). Consistent low or high depression scores did not significantly influence the odds of PTB compared to a decrease in depression scores. A co-occurring increase in anxiety and depression scores was not found to increase the risk of PTB, and chronic stress did not modify any of these relationships. LIMITATIONS: This study was limited by a relatively small sample of women who delivered preterm, and therefore it was not possible to conduct additional analyses. Further, the analyses were limited to mostly late preterm infants (32-36 weeks' gestation). CONCLUSIONS: These findings should be validated with additional cohorts and a larger sample size. Ultimately, primary prevention could address anxiety during pregnancy.
Authors: I Kleine; S Falconer; S Roth; S J Counsell; M Redshaw; N Kennea; A D Edwards; C Nosarti Journal: J Psychiatr Res Date: 2020-09-14 Impact factor: 4.791
Authors: Beatriz Pereira; Bárbara Figueiredo; Tiago Miguel Pinto; M Carmen Míguez Journal: Int J Environ Res Public Health Date: 2020-11-04 Impact factor: 3.390