Joel B Epstein1,2, Judith E Raber-Durlacher3,4, Marie-Charlotte Huysmans5, Maria C E Schoordijk6, Jerry E Cheng2,7, Rene-Jean Bensadoun8, Praveen R Arany9. 1. 1 Cancer Dentistry, Samuel Oschin Comprehensive Cancer Institute , Cedars-Sinai Health Center, Los Angeles, California. 2. 2 Department of Oral Medicine, City of Hope , Duarte, California. 3. 3 Department of Oral and Maxillofacial Surgery, Academic Medical Center , Amsterdam, The Netherlands . 4. 4 Department of Oral Medicine, and Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam , Amsterdam, The Netherlands . 5. 5 Department of Dentistry, Radboud University Medical Center , Nijmegen, The Netherlands . 6. 6 Department of Hematology, VU University Amsterdam , The Netherlands . 7. 7 Kaiser Permanente , Los Angeles, California. 8. 8 Centre de Haute Engergie , Nice, France . 9. 9 Department of Oral Biology, School of Dental Medicine, University at Buffalo , Buffalo, New York.
Abstract
OBJECTIVE: Patients who receive allogeneic hematopoietic stem cell transplantation may experience oral complications due to chronic graft-versus-host disease (cGVHD). The manifestations may include progressive sclerosis-like changes that may involve various body sites, including the oropharynx. METHODS AND RESULTS: We present two cGVHD cases of oropharyngeal fibrotic changes that affected functions that were treated with photobiomodulation (PBM) therapy. These case reports suggest that PBM therapy represents an additional, innovative approach affecting discrete phases in cGVHD-associated fibrotic changes. CONCLUSIONS: We discuss these observations in the context of currently understood molecular mechanisms, especially induction of transforming growth factor beta and NFκB that appear to be counter-intuitive to their known roles in matrix synthesis and inflammation that contribute to tissue fibroses. The clinical benefit noted in the two cases presented clearly indicates that there are distinct mechanistic and biological insights in the regulation of these molecular pathways in determining therapeutic efficacy with PBM therapy.
OBJECTIVE:Patients who receive allogeneic hematopoietic stem cell transplantation may experience oral complications due to chronic graft-versus-host disease (cGVHD). The manifestations may include progressive sclerosis-like changes that may involve various body sites, including the oropharynx. METHODS AND RESULTS: We present two cGVHD cases of oropharyngeal fibrotic changes that affected functions that were treated with photobiomodulation (PBM) therapy. These case reports suggest that PBM therapy represents an additional, innovative approach affecting discrete phases in cGVHD-associated fibrotic changes. CONCLUSIONS: We discuss these observations in the context of currently understood molecular mechanisms, especially induction of transforming growth factor beta and NFκB that appear to be counter-intuitive to their known roles in matrix synthesis and inflammation that contribute to tissue fibroses. The clinical benefit noted in the two cases presented clearly indicates that there are distinct mechanistic and biological insights in the regulation of these molecular pathways in determining therapeutic efficacy with PBM therapy.
Authors: Jefferson André Pires; Erick Frank Bragato; Marcos Momolli; Marina Bertoni Guerra; Leonel Manea Neves; Meire Augusto de Oliveira Bruscagnin; Anna Carolina Ratto Tempestini Horliana; Kristianne Porta Santos Fernandes; Sandra Kalil Bussadori; Raquel Agnelli Mesquita Ferrari Journal: PLoS One Date: 2022-02-15 Impact factor: 3.240
Authors: Jolien Robijns; Raj G Nair; Joy Lodewijckx; Praveen Arany; Andrei Barasch; Jan M Bjordal; Paolo Bossi; Anne Chilles; Patricia M Corby; Joel B Epstein; Sharon Elad; Reza Fekrazad; Eduardo Rodrigues Fregnani; Marie-Thérèse Genot; Ana M C Ibarra; Michael R Hamblin; Vladimir Heiskanen; Ken Hu; Jean Klastersky; Rajesh Lalla; Sofia Latifian; Arun Maiya; Jeroen Mebis; Cesar A Migliorati; Dan M J Milstein; Barbara Murphy; Judith E Raber-Durlacher; Hendrik J Roseboom; Stephen Sonis; Nathaniel Treister; Yehuda Zadik; René-Jean Bensadoun Journal: Front Oncol Date: 2022-08-30 Impact factor: 5.738
Authors: René-Jean Bensadoun; Joel B Epstein; Raj G Nair; Andrei Barasch; Judith E Raber-Durlacher; Cesar Migliorati; Marie-Thérèse Genot-Klastersky; Nathaniel Treister; Praveen Arany; Joy Lodewijckx; Jolien Robijns Journal: Cancer Med Date: 2020-10-26 Impact factor: 4.452