Bo Ding1, Mark Small2. 1. Medical Evidence and Observational Research, AstraZeneca Gothenburg, Mölndal, Sweden. 2. Respiratory Research, Adelphi Real World, Macclesfield, UK.
Abstract
BACKGROUND AND OBJECTIVE: The impact, treatment patterns and control of mild asthma are poorly understood for Chinese patients. This study describes the characteristics, therapeutic interventions and burden of mild asthma on patients residing in major cities of China. METHODS: The Respiratory Disease Specific Program 2015, a cross-sectional survey, was conducted with Chinese physicians and their patients. The survey assessed clinical characteristics, asthma symptoms, exacerbations, rescue inhaler usage, treatment adherence, asthma control, work and activity impairments and healthcare utilization for patients prescribed Global Initiative for Asthma (GINA) Step 1 or 2 treatment defined mild asthma. RESULTS: From a total sample of 988 patients, 229 patients met the criteria for mild asthma, with 25.3% classified as Step 1 and 74.7% as Step 2. Overall, 12.6% of patients were considered of high adherence to prescribed treatment. Physicians reported that 75% of patients overall were well controlled, although well-controlled asthma as defined by GINA was achieved in only 14.2% of patients. 26.5% of patients indicated daily use of as-needed rescue medication in the last 4 weeks. 17.8% of patients experienced ≥1 exacerbations in the last 12 months and impaired work productivity was 27.2% overall. CONCLUSION: Less than 15% of patients were well controlled according to GINA criteria despite physicians reporting the majority of patients were well controlled. Over one-fourth of patients relied on daily rescue inhaler medication, while exacerbation frequency and work and activity impairment were higher than might reasonably be expected in a mild asthmatic population.
BACKGROUND AND OBJECTIVE: The impact, treatment patterns and control of mild asthma are poorly understood for Chinese patients. This study describes the characteristics, therapeutic interventions and burden of mild asthma on patients residing in major cities of China. METHODS: The Respiratory Disease Specific Program 2015, a cross-sectional survey, was conducted with Chinese physicians and their patients. The survey assessed clinical characteristics, asthma symptoms, exacerbations, rescue inhaler usage, treatment adherence, asthma control, work and activity impairments and healthcare utilization for patients prescribed Global Initiative for Asthma (GINA) Step 1 or 2 treatment defined mild asthma. RESULTS: From a total sample of 988 patients, 229 patients met the criteria for mild asthma, with 25.3% classified as Step 1 and 74.7% as Step 2. Overall, 12.6% of patients were considered of high adherence to prescribed treatment. Physicians reported that 75% of patients overall were well controlled, although well-controlled asthma as defined by GINA was achieved in only 14.2% of patients. 26.5% of patients indicated daily use of as-needed rescue medication in the last 4 weeks. 17.8% of patients experienced ≥1 exacerbations in the last 12 months and impaired work productivity was 27.2% overall. CONCLUSION: Less than 15% of patients were well controlled according to GINA criteria despite physicians reporting the majority of patients were well controlled. Over one-fourth of patients relied on daily rescue inhaler medication, while exacerbation frequency and work and activity impairment were higher than might reasonably be expected in a mild asthmatic population.
Authors: Huidi Liu; Huibo Li; Dirk E Teuwen; Sean Sylvia; Haonan Shi; Scott Rozelle; Hongmei Yi Journal: Front Pharmacol Date: 2022-02-15 Impact factor: 5.810
Authors: Evalyne M Jansen; Susanne J van de Hei; Boudewijn J H Dierick; Huib A M Kerstjens; Janwillem W H Kocks; Job F M van Boven Journal: J Thorac Dis Date: 2021-06 Impact factor: 2.895
Authors: Evelyn A Brakema; Aizhamal Tabyshova; Rianne M J J van der Kleij; Talant Sooronbaev; Christos Lionis; Marilena Anastasaki; Pham Le An; Luan Than Nguyen; Bruce Kirenga; Simon Walusimbi; Maarten J Postma; Niels H Chavannes; Job F M van Boven Journal: Respir Res Date: 2019-12-21