Literature DB >> 2905271

6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor.

P J Birch1, C J Grossman, A G Hayes.   

Abstract

6,7-Dinitro-quinoxaline-2,3-dion (DNQX) and 6-nitro,7-cyano-quinoxaline-2,3-dion (CNQX) produce an unsurmountable antagonism of responses to N-methyl-D-aspartate (NMDA) in the baby rat hemisected spinal cord. These effects of DNQX and CNQX can be prevented in a dose-dependent manner by co-superfusion with D-serine or glycine (in the presence of strychnine). The results suggest that the unsurmountable blockade of NMDA responses by DNQX and CNQX reflects an antagonist effect mediated at the allosterically linked strychnine-insensitive glycine receptor.

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Year:  1988        PMID： 2905271     DOI： 10.1016/0014-2999(88)90163-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  28 in total

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4.  Modulation of N-methyl-D-aspartate receptor function by glycine transport.

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Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

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6.  Cycloleucine blocks NMDA responses in cultured hippocampal neurones under voltage clamp: antagonism at the strychnine-insensitive glycine receptor.

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7.  Actions of agonists of metabotropic glutamate receptors on synaptic transmission and transmitter release in the olfactory cortex.

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Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

8.  Developmental expression of N-methyl-D-aspartate (NMDA)-induced neurotoxicity, NMDA receptor function, and the NMDAR1 and glutamate-binding protein subunits in cerebellar granule cells in primary cultures.

Authors:  Y Xia; R E Ragan; E E Seah; M L Michaelis; E K Michaelis
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9.  Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro.

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