Literature DB >> 29052670

Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential.

Peng Teng1, Alekhya Nimmagadda, Ma Su, Yuzhu Hong, Ning Shen, Chunpu Li, Ling-Yu Tsai, Jessica Cao, Qi Li, Jianfeng Cai.   

Abstract

We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model.

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Year:  2017        PMID： 29052670      PMCID： PMC5690803          DOI： 10.1039/c7cc07285f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  38 in total

Review 1.  Colistin: new lessons on an old antibiotic.

Authors:  D Yahav; L Farbman; L Leibovici; M Paul
Journal:  Clin Microbiol Infect       Date:  2012-01       Impact factor: 8.067

Review 2.  Antibacterial peptides for therapeutic use: obstacles and realistic outlook.

Authors:  Alexandra K Marr; William J Gooderham; Robert Ew Hancock
Journal:  Curr Opin Pharmacol       Date:  2006-08-04       Impact factor: 5.547

3.  Toroidal pores formed by antimicrobial peptides show significant disorder.

Authors:  Durba Sengupta; Hari Leontiadou; Alan E Mark; Siewert-Jan Marrink
Journal:  Biochim Biophys Acta       Date:  2008-06-18

4.  Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections.

Authors:  Jun-Jie Koh; Shuimu Lin; Thet Tun Aung; Fanghui Lim; Hanxun Zou; Yang Bai; Jianguo Li; Huifen Lin; Li Mei Pang; Wee Luan Koh; Shuhaida Mohamed Salleh; Rajamani Lakshminarayanan; Lei Zhou; Shengxiang Qiu; Konstantin Pervushin; Chandra Verma; Donald T H Tan; Derong Cao; Shouping Liu; Roger W Beuerman
Journal:  J Med Chem       Date:  2014-12-17       Impact factor: 7.446

Review 5.  Recent development of small antimicrobial peptidomimetics.

Authors:  Youhong Niu; Rongsheng E Wang; Haifan Wu; Jianfeng Cai
Journal:  Future Med Chem       Date:  2012-09       Impact factor: 3.808

6.  Antibacterial Diamines Targeting Bacterial Membranes.

Authors:  Bo Wang; Boobalan Pachaiyappan; Jordon D Gruber; Michael G Schmidt; Yong-Mei Zhang; Patrick M Woster
Journal:  J Med Chem       Date:  2016-03-28       Impact factor: 7.446

7.  Antibacterial mechanism of action of arylamide foldamers.

Authors:  Bruk Mensa; Yong Ho Kim; Sungwook Choi; Richard Scott; Gregory A Caputo; William F DeGrado
Journal:  Antimicrob Agents Chemother       Date:  2011-08-15       Impact factor: 5.191

8.  Symmetrically Substituted Xanthone Amphiphiles Combat Gram-Positive Bacterial Resistance with Enhanced Membrane Selectivity.

Authors:  Shuimu Lin; Jun-Jie Koh; Thet Tun Aung; Fanghui Lim; Jianguo Li; Hanxun Zou; Lin Wang; Rajamani Lakshminarayanan; Chandra Verma; Yingjun Wang; Donald T H Tan; Derong Cao; Roger W Beuerman; Li Ren; Shouping Liu
Journal:  J Med Chem       Date:  2017-02-13       Impact factor: 7.446

Review 9.  Daptomycin, a lipopeptide antibiotic in clinical practice.

Authors:  Florian Weis; Andres Beiras-Fernandez; Gustav Schelling
Journal:  Curr Opin Investig Drugs       Date:  2008-08

10.  Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway.

Authors:  Sung Ryeol Park; Ashootosh Tripathi; Jianfeng Wu; Pamela J Schultz; Isaiah Yim; Thomas J McQuade; Fengan Yu; Carl-Johan Arevang; Abraham Y Mensah; Giselle Tamayo-Castillo; Chuanwu Xi; David H Sherman
Journal:  Nat Commun       Date:  2016-02-16       Impact factor: 14.919
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  8 in total

1.  Antibacterial activity of lipo-α/sulfono-γ-AA hybrid peptides.

Authors:  Lulu Wei; Minghui Wang; Ruixuan Gao; Rojin Fatirkhorani; Jianfeng Cai
Journal:  Eur J Med Chem       Date:  2019-11-19       Impact factor: 6.514

Review 2.  Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?

Authors:  Johan Svenson; Natalia Molchanova; Christina I Schroeder
Journal:  Front Immunol       Date:  2022-05-26       Impact factor: 8.786

3.  Bis-Cyclic Guanidines as a Novel Class of Compounds Potent against Clostridium difficile.

Authors:  Chunhui Li; Peng Teng; Zhong Peng; Peng Sang; Xingmin Sun; Jianfeng Cai
Journal:  ChemMedChem       Date:  2018-06-14       Impact factor: 3.466

4.  Dimeric lipo-α/sulfono-γ-AA hybrid peptides as broad-spectrum antibiotic agents.

Authors:  Lulu Wei; Ruixuan Gao; Minghui Wang; Yafeng Wang; Yan Shi; Meng Gu; Jianfeng Cai
Journal:  Biomater Sci       Date:  2021-05-04       Impact factor: 6.843

5.  Dimeric γ-AApeptides With Potent and Selective Antibacterial Activity.

Authors:  Minghui Wang; Ruixuan Gao; Peng Sang; Timothy Odom; Mengmeng Zheng; Yan Shi; Hai Xu; Chuanhai Cao; Jianfeng Cai
Journal:  Front Chem       Date:  2020-06-12       Impact factor: 5.221

6.  Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents.

Authors:  Minghui Wang; Ruixuan Gao; Mengmeng Zheng; Peng Sang; Chunpu Li; En Zhang; Qi Li; Jianfeng Cai
Journal:  J Med Chem       Date:  2020-09-24       Impact factor: 7.446

7.  A Novel Class of Cationic and Non-Peptidic Small Molecules as Hits for the Development of Antimicrobial Agents.

Authors:  Aranza Jiménez; Pablo García; Sofia de la Puente; Andrés Madrona; María José Camarasa; María-Jesús Pérez-Pérez; José-Carlos Quintela; Francisco García-Del Portillo; Ana San-Félix
Journal:  Molecules       Date:  2018-06-22       Impact factor: 4.411

8.  Small AntiMicrobial Peptide With in Vivo Activity Against Sepsis.

Authors:  Héloise Boullet; Fayçal Bentot; Arnaud Hequet; Carine Ganem-Elbaz; Chérine Bechara; Emeline Pacreau; Pierre Launay; Sandrine Sagan; Claude Jolivalt; Claire Lacombe; Roba Moumné; Philippe Karoyan
Journal:  Molecules       Date:  2019-05-01       Impact factor: 4.411
  8 in total

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