| Literature DB >> 2905198 |
R E Schmidt1, D A Plurad, K A Roth.
Abstract
Immunohistologic localization of tyrosine hydroxylase (TOH), dopamine-beta-hydroxylase (DBH) and selected neuropeptides (vasoactive intestinal polypeptide, gastrin-releasing peptide (GRP)/bombesin, substance P, Leu-enkephalin, Met-enkephalin, dynorphin B, neuropeptide Y (NPY), somatostatin) was used to investigate the innervation of the small bowel in a rat model of diabetic autonomic neuropathy. Paravascular mesenteric nerves (extrinsic) and intramural nerves of chronically (12-18 month) diabetic rats were characterized by the presence of numerous, markedly swollen dystrophic axons which stained intensely for TOH and DBH. The peptidergic complement of axons, however, showed no evidence of comparable dystrophic axonopathy.Entities:
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Year: 1988 PMID： 2905198 DOI： 10.1016/0006-8993(88)90478-7
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252