| Literature DB >> 29050940 |
Qianwen Shao1, Jing Xu2, Rong Deng3, Wei Wei3, Bing Zhou3, Chao Yue3, Miaoling Zhu4, Xingen Huang5, Haitao Zhu6.
Abstract
Colorectal cancer (CRC) is one of the most frequent cancer in numerous of countries worldwidely. The initiation and progression of CRC is an extremely complex process, and have been suggested a correlation with Long non-coding RNAs (lncRNAs). Our results showed that lncRNA-422(ENST00000415820) significantly downregulated in the tissues and serum of CRC patients, and is closely associated with the poor prognosis. Then gain or loss of lncRNA-422 models in SW480 and SW620cells were established. The results showed that lncRNA-422 overexpression inhibited cell proliferation, migration, and invasion. Knockdown of lncRNA-422 promoted tumorigensis. Western blot and qRT-PCR were performed to examine the activity of the PI3K/AKT/mTOR pathway in CRC cells after alternation of lncRNA-422. Results showed that lncRNA-422 acts as a tumor suppressor by PI3K/AKT/mTOR pathway in CRC.Entities:
Keywords: Apoptosis; Colorectal cancer; PI3K/AKT/mTOR; Proliferation; lncRNA-422
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Year: 2017 PMID： 29050940 DOI： 10.1016/j.bbrc.2017.10.076
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575