| Literature DB >> 2904995 |
C T Eason1, A Pattison, D D Howells, F W Bonner.
Abstract
The potential of ciprofibrate to inhibit gastric secretion has been investigated in the rat. A significant gastric antisecretory effect was observed following a single oral administration of 300 and 500 mg kg-1 and following a single intraduodenal dose of 100, 300 and 500 mg kg-1. The toxicological significance of this finding is discussed in the light of a spate of recent publications linking changes in gastric morphology with hypergastrinaemia produced as a secondary effect of inhibition of acid secretion.Entities:
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Year: 1988 PMID： 2904995 DOI： 10.1111/j.2042-7158.1988.tb05289.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765