Wei-Syun Hu1, Cheng-Li Lin2. 1. School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan; Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung 40447, Taiwan. Electronic address: weisyunhu@gmail.com. 2. Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan.
Abstract
BACKGROUND AND AIMS: The current study was conducted to assess the ability of CHA2DS2-VASc, CHADS2 and HATCH scores in predicting new-onset atrial fibrillation (AF) among patients with cancer. METHODS: Patients with newly diagnosed cancer between 1 January, 2000 and 31 December, 2011, from the Registry for Catastrophic Illness Patient Database, were defined as the study cohort. CHA2DS2-VASc, CHADS2 and HATCH scores were used for new-onset AF prediction in these study patients, and the predictive accuracy of the scores was assessed by the receiver operating characteristics (ROC) curve. RESULTS: A total of 760,339 cancer patients were identified as the study participants. The ROC curves were 0.68 (95% confidence interval [CI] = 0.68-0.69) for the CHA2DS2-VASc score, 0.67 (95% CI = 0.67-0.68) for the CHADS2 score and 0.69 (95% CI = 0.69-0.70) for the HATCH score. There were significant differences of c-statistics among CHA2DS2-VASc score, CHADS2 score and HATCH score (CHA2DS2-VASc score vs. CHADS2 score, p = 0.01; CHA2DS2-VASc score vs. HATCH score, p = 0.002; CHADS2 score vs. HATCH score, p < 0.001). CONCLUSIONS: The current study is the first to assess the prognostic value of 3 AF risk scores (CHA2DS2-VASc, CHADS2 and HATCH scores) in patients with newly-diagnosed cancer. HATCH score was found to have a slightly but significantly better predictive performance than the other 2 scores.
BACKGROUND AND AIMS: The current study was conducted to assess the ability of CHA2DS2-VASc, CHADS2 and HATCH scores in predicting new-onset atrial fibrillation (AF) among patients with cancer. METHODS:Patients with newly diagnosed cancer between 1 January, 2000 and 31 December, 2011, from the Registry for Catastrophic Illness Patient Database, were defined as the study cohort. CHA2DS2-VASc, CHADS2 and HATCH scores were used for new-onset AF prediction in these study patients, and the predictive accuracy of the scores was assessed by the receiver operating characteristics (ROC) curve. RESULTS: A total of 760,339 cancerpatients were identified as the study participants. The ROC curves were 0.68 (95% confidence interval [CI] = 0.68-0.69) for the CHA2DS2-VASc score, 0.67 (95% CI = 0.67-0.68) for the CHADS2 score and 0.69 (95% CI = 0.69-0.70) for the HATCH score. There were significant differences of c-statistics among CHA2DS2-VASc score, CHADS2 score and HATCH score (CHA2DS2-VASc score vs. CHADS2 score, p = 0.01; CHA2DS2-VASc score vs. HATCH score, p = 0.002; CHADS2 score vs. HATCH score, p < 0.001). CONCLUSIONS: The current study is the first to assess the prognostic value of 3 AF risk scores (CHA2DS2-VASc, CHADS2 and HATCH scores) in patients with newly-diagnosed cancer. HATCH score was found to have a slightly but significantly better predictive performance than the other 2 scores.