| Literature DB >> 29047270 |
Shang-Shi Zhang1, Jie Xia1, Jia-Qiang Wu1, Xu-Ge Liu1, Chu-Jun Zhou1, E Lin1, Qingjiang Li1, Shi-Liang Huang1, Honggen Wang1.
Abstract
A novel cascade Cp*Rh(III)-catalyzed C-H alkylation/Cu(II)-promoted α-oxygenation which enabled a three-component carboxygenation of activated alkene is reported. Mild reaction conditions, broad substrate scope, and good functional group tolerance were observed. The synthetic utility of the protocol was showcased by the facile transformations of the product to a variety of structurally diverse molecules. Preliminary mechanistic studies were conducted.Entities:
Year: 2017 PMID： 29047270 DOI： 10.1021/acs.orglett.7b02846
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005