Vicente Morales-Oyarvide1, Mari Mino-Kenudson2, Cristina R Ferrone1, Andrew L Warshaw1, Keith D Lillemoe1, Dushyant V Sahani3, Ilaria Pergolini1, Marc A Attiyeh4, Mohammad Al Efishat4, Neda Rezaee5, Ralph H Hruban6,7, Jin He5, Matthew J Weiss5, Peter J Allen4, Christopher L Wolfgang5, Carlos Fernández-Del Castillo8. 1. Department of Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Wang Ambulatory Care Center 460, Boston, MA, 02114, USA. 2. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 3. Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 4. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 5. Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 7. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 8. Department of Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Wang Ambulatory Care Center 460, Boston, MA, 02114, USA. cfernandez@partners.org.
Abstract
AIM: The aim of this paper is to describe the characteristics of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in young patients. METHODS: We evaluated 1693 patients from the Pancreatic Surgery Consortium who underwent resection for IPMN and classified them as younger or older than 50 years of age at the time of surgery. We assessed the relationship of age with clinical, radiological, pathological, and prognostic features. RESULTS: We identified 90 (5%) young patients. Age was not associated with differences in main pancreatic duct size (P = 0.323), presence of solid components (P = 0.805), or cyst size (P = 0.135). IPMNs from young patients were less likely to be of gastric type (37 vs. 57%, P = 0.005), and more likely to be of oncocytic (15 vs. 4%, P = 0.003) and intestinal types (44 vs. 26%, P = 0.004). Invasive carcinomas arising from IPMN were less common in young patients (17 vs. 27%, P = 0.044), and when present they were commonly of colloid type (47 vs. 31% in older patients, P = 0.261) and had better overall survival than older patients (5-year, 71 vs. 37%, log-rank P = 0.031). CONCLUSION: Resection for IPMN is infrequent in young patients, but when they are resected, IPMNs from young patients demonstrate different epithelial subtypes from those in older patients and more favorable prognosis.
AIM: The aim of this paper is to describe the characteristics of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in young patients. METHODS: We evaluated 1693 patients from the Pancreatic Surgery Consortium who underwent resection for IPMN and classified them as younger or older than 50 years of age at the time of surgery. We assessed the relationship of age with clinical, radiological, pathological, and prognostic features. RESULTS: We identified 90 (5%) young patients. Age was not associated with differences in main pancreatic duct size (P = 0.323), presence of solid components (P = 0.805), or cyst size (P = 0.135). IPMNs from young patients were less likely to be of gastric type (37 vs. 57%, P = 0.005), and more likely to be of oncocytic (15 vs. 4%, P = 0.003) and intestinal types (44 vs. 26%, P = 0.004). Invasive carcinomas arising from IPMN were less common in young patients (17 vs. 27%, P = 0.044), and when present they were commonly of colloid type (47 vs. 31% in older patients, P = 0.261) and had better overall survival than older patients (5-year, 71 vs. 37%, log-rank P = 0.031). CONCLUSION: Resection for IPMN is infrequent in young patients, but when they are resected, IPMNs from young patients demonstrate different epithelial subtypes from those in older patients and more favorable prognosis.
Entities:
Keywords:
IPMN; Pancreatic cystic neoplasms; Young
Authors: Klaus Sahora; Mari Mino-Kenudson; William Brugge; Sarah P Thayer; Cristina R Ferrone; Dushyant Sahani; Martha B Pitman; Andrew L Warshaw; Keith D Lillemoe; Carlos F Fernandez-del Castillo Journal: Ann Surg Date: 2013-09 Impact factor: 12.969
Authors: Giovanni Marchegiani; Mari Mino-Kenudson; Cristina R Ferrone; Andrew L Warshaw; Keith D Lillemoe; Carlos Fernández-del Castillo Journal: J Am Coll Surg Date: 2015-02-11 Impact factor: 6.113
Authors: Mari Mino-Kenudson; Carlos Fernández-del Castillo; Yoshifumi Baba; Nakul P Valsangkar; Andrew S Liss; Maylee Hsu; Camilo Correa-Gallego; Thun Ingkakul; Rocio Perez Johnston; Brian G Turner; Vasiliki Androutsopoulos; Vikram Deshpande; Deborah McGrath; Dushyant V Sahani; William R Brugge; Shuji Ogino; Martha B Pitman; Andrew L Warshaw; Sarah P Thayer Journal: Gut Date: 2011-04-20 Impact factor: 23.059
Authors: R A Carr; A M Roch; K Shaffer; S Aboudi; C M Schmidt; J DeWitt; E P Ceppa; M G House; N J Zyromski; A Nakeeb; C M Schmidt Journal: Am J Surg Date: 2016-12-28 Impact factor: 2.565
Authors: Jian Wu; Hanno Matthaei; Anirban Maitra; Marco Dal Molin; Laura D Wood; James R Eshleman; Michael Goggins; Marcia I Canto; Richard D Schulick; Barish H Edil; Christopher L Wolfgang; Alison P Klein; Luis A Diaz; Peter J Allen; C Max Schmidt; Kenneth W Kinzler; Nickolas Papadopoulos; Ralph H Hruban; Bert Vogelstein Journal: Sci Transl Med Date: 2011-07-20 Impact factor: 17.956
Authors: Thomas A Laffan; Karen M Horton; Alison P Klein; Bruce Berlanstein; Stanley S Siegelman; Satomi Kawamoto; Pamela T Johnson; Elliot K Fishman; Ralph H Hruban Journal: AJR Am J Roentgenol Date: 2008-09 Impact factor: 3.959
Authors: Thomas Schnelldorfer; Michael G Sarr; David M Nagorney; Lizhi Zhang; Thomas C Smyrk; Rui Qin; Suresh T Chari; Michael B Farnell Journal: Arch Surg Date: 2008-07
Authors: Amanda L Blackford; Marcia Irene Canto; Alison P Klein; Ralph H Hruban; Michael Goggins Journal: J Natl Cancer Inst Date: 2020-11-01 Impact factor: 13.506