Zhifeng Zhang1, Haihua Xu2, Yunhui Zhang3, Wei Li3, Yanjie Yang3, Tian Han4, Zhihui Wei4, Xue Xu3, Jingui Gao5. 1. Department of Pain Treatment, the Second Hospital of Tianjin Medical University, Tianjin 300211, China. 2. Department of Urinary Surgery, the Children's Hospital in Tianjin, Tianjin 300074, China. 3. Department of Anesthesia, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China. 4. Department of Anesthesia, Baoding NO.2 Central Hospital, Baoding 072750, China. 5. Department of Anesthesia, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China. Electronic address: gaojingui@126.com.
Abstract
STUDY OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) play a role in pain relief, especially in postoperative pain caused by inflammation. They have demonstrated significant opioid dose-sparing effects, which help in reducing postoperative effects and opioid side effects. The objective of this meta-analysis was to explore the role of NSAIDs in reducing postoperative pain at different time intervals and provide reference for medication after lumbar spine surgery by a meta-analysis of randomized controlled trials (RCT). DESIGN: A meta-analysis study of randomized controlled trials. SETTING: Postoperative recovery area. PATIENTS: Adult patients who have undergone lumbar spine surgery. INTERVENTION: Patients received NSAIDs for pain control after lumbar spine surgery. MEASUREMENTS: Standardized mean difference (SMD) and 95%CI were used to evaluate the visual analog scale of postoperative pain. MAIN RESULTS: Four hundred and eight participants from eight studies were included in this study. The difference between the NSAIDs group and placebo is significant in 0-6, 12, and 24h groups (overall: SMD=-0.72, 95%CI -0.98 to -0.45; 0-6h: SMD=0.50, 95%CI -0.81 to -0.19; 12h: SMD=-1.07, 95%CI -1.45 to -0.70; 24h: SMD=-1.16, 95%CI -1.87 to -0.45). Heterogeneity and publication bias were observed in the 0-6 and 24h groups. CONCLUSION: NSAIDs are effective in postoperative analgesia after lumbar spine surgery. The study type, NSAID dose, different surgery types, and analgesic type might influence the efficacy of NSAIDs.
STUDY OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) play a role in pain relief, especially in postoperative pain caused by inflammation. They have demonstrated significant opioid dose-sparing effects, which help in reducing postoperative effects and opioid side effects. The objective of this meta-analysis was to explore the role of NSAIDs in reducing postoperative pain at different time intervals and provide reference for medication after lumbar spine surgery by a meta-analysis of randomized controlled trials (RCT). DESIGN: A meta-analysis study of randomized controlled trials. SETTING: Postoperative recovery area. PATIENTS: Adult patients who have undergone lumbar spine surgery. INTERVENTION: Patients received NSAIDs for pain control after lumbar spine surgery. MEASUREMENTS: Standardized mean difference (SMD) and 95%CI were used to evaluate the visual analog scale of postoperative pain. MAIN RESULTS: Four hundred and eight participants from eight studies were included in this study. The difference between the NSAIDs group and placebo is significant in 0-6, 12, and 24h groups (overall: SMD=-0.72, 95%CI -0.98 to -0.45; 0-6h: SMD=0.50, 95%CI -0.81 to -0.19; 12h: SMD=-1.07, 95%CI -1.45 to -0.70; 24h: SMD=-1.16, 95%CI -1.87 to -0.45). Heterogeneity and publication bias were observed in the 0-6 and 24h groups. CONCLUSION: NSAIDs are effective in postoperative analgesia after lumbar spine surgery. The study type, NSAID dose, different surgery types, and analgesic type might influence the efficacy of NSAIDs.
Authors: Ellen M Soffin; Carrie Freeman; Alexander P Hughes; Douglas S Wetmore; Stavros G Memtsoudis; Federico P Girardi; Haoyan Zhong; James D Beckman Journal: Eur Spine J Date: 2019-07-27 Impact factor: 3.134
Authors: Nguyen Trung Kien; Phillip Geiger; Hoang Van Chuong; Nguyen Manh Cuong; Ngo Van Dinh; Dinh Cong Pho; Vu The Anh; Nguyen Truong Giang Journal: Drug Des Devel Ther Date: 2019-07-03 Impact factor: 4.162